(S)-methyl 3-cyclopropyl-3-(3-((2'-fluoro-5'-methoxy-2-((R)-1-methoxy-2,2-dimethylpropyl)-[1,1'-biphenyl]-4-yl)methoxy)phenyl)propanoate

Base Information

• Chemical Name: (S)-methyl 3-cyclopropyl-3-(3-((2'-fluoro-5'-methoxy-2-((R)-1-methoxy-2,2-dimethylpropyl)-[1,1'-biphenyl]-4-yl)methoxy)phenyl)propanoate
• CAS No.: 1556954-42-7
• Molecular Formula: C₃₃H₃₉FO₅
• Molecular Weight: 534.668
• Mol file: 1556954-42-7.mol

Synonyms:(S)-methyl 3-cyclopropyl-3-(3-((2'-fluoro-5'-methoxy-2-((R)-1-methoxy-2,2-dimethylpropyl)-[1,1'-biphenyl]-4-yl)methoxy)phenyl)propanoate

Chemical Property of (S)-methyl 3-cyclopropyl-3-(3-((2'-fluoro-5'-methoxy-2-((R)-1-methoxy-2,2-dimethylpropyl)-[1,1'-biphenyl]-4-yl)methoxy)phenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-methyl 3-cyclopropyl-3-(3-((2'-fluoro-5'-methoxy-2-((R)-1-methoxy-2,2-dimethylpropyl)-[1,1'-biphenyl]-4-yl)methoxy)phenyl)propanoate

There total 2 articles about (S)-methyl 3-cyclopropyl-3-(3-((2'-fluoro-5'-methoxy-2-((R)-1-methoxy-2,2-dimethylpropyl)-[1,1'-biphenyl]-4-yl)methoxy)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl (3S)-3-cyclopropyl-3-(3-hydroxyphenyl)propanoate (1142223-08-2,1142224-62-1) + (R)-4-(chloromethyl)-2'-fluoro-5'-methoxy-2-(1-methoxy-2,2-dimethylpropyl)-1,1'-biphenyl (1142225-30-6) → (S)-methyl 3-cyclopropyl-3-(3-((2'-fluoro-5'-methoxy-2-((R)-1-methoxy-2,2-dimethylpropyl)-[1,1'-biphenyl]-4-yl)methoxy)phenyl)propanoate (1556954-42-7)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 23 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ml4005123

Reference yield:

(R)-tert-butyl((2'-fluoro-5'-methoxy-2-(1-methoxy-2,2-dimethylpropyl)-[1,1'-biphenyl]-4-yl)methoxy)dimethylsilane (1142225-26-0) → (S)-methyl 3-cyclopropyl-3-(3-((2'-fluoro-5'-methoxy-2-((R)-1-methoxy-2,2-dimethylpropyl)-[1,1'-biphenyl]-4-yl)methoxy)phenyl)propanoate (1556954-42-7)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / N,N-dimethyl-formamide; dichloromethane / 1 h / 23 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 16 h / 23 °C / Inert atmosphere

With thionyl chloride; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ml4005123

Reference yield: 72.0%

(S)-methyl 3-cyclopropyl-3-(3-((2'-fluoro-5'-methoxy-2-((R)-1-methoxy-2,2-dimethylpropyl)-[1,1'-biphenyl]-4-yl)methoxy)phenyl)propanoate (1556954-42-7) → (S)-3-cyclopropyl-3-(3-((2'-fluoro-5'-methoxy-2-((R)-1-methoxy-2,2-dimethylpropyl)-[1,1'-biphenyl]-4-yl)methoxy)phenyl)propanoic acid

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; ethanol; at 23 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ml4005123

upstream raw materials:

methyl (3S)-3-cyclopropyl-3-(3-hydroxyphenyl)propanoate

(R)-4-(chloromethyl)-2'-fluoro-5'-methoxy-2-(1-methoxy-2,2-dimethylpropyl)-1,1'-biphenyl

(R)-tert-butyl((2'-fluoro-5'-methoxy-2-(1-methoxy-2,2-dimethylpropyl)-[1,1'-biphenyl]-4-yl)methoxy)dimethylsilane