(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (3S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanamide

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Chemical Name:(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (3S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanamide
CAS No.:1330630-62-0
Molecular Formula:C₄₀H₄₄N₂O₂
Molecular Weight:584.802
Hs Code.:

Synonyms:(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (3S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanamide

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Chemical Property of (S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (3S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanamide

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Technology Process of (S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (3S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanamide

There total 6 articles about (S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (3S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1330630-58-4
(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (E)-3-phenylpropenamide

: 38235-77-7
(R)-N-benzyl-1-phenylethylamine

: 1330630-62-0
(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (3S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanamide

Guidance literature:: (R)-N-benzyl-1-phenylethylamine; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 0.5h; Inert atmosphere;

(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (E)-3-phenylpropenamide; In tetrahydrofuran; hexanes; at -78 ℃; for 2h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2011.05.102

Reference yield:

: 1177266-31-7
(S)-N-1-(1'-naphthyl)ethyl-O-tert-butylhydroxylamine (+)-camphorsulfonic acid salt

: C₂₄H₂₄ClNO

: 1330630-62-0
(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (3S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanamide

Guidance literature:: With potassium carbonate; In dichloromethane; Inert atmosphere;
DOI:10.1016/j.tet.2011.05.102

Reference yield:

: (3S,αR)-3-N-benzyl-N-α-methylbenzylamino-3-phenylpropanoic acid

: 1330630-62-0
(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (3S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate / dichloromethane / Inert atmosphere

With oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1016/j.tet.2011.05.102