3-(2-benzyloxy-phenyl)-2-methoxy-5-methyl-benzofuran

Base Information

Chemical Name:3-(2-benzyloxy-phenyl)-2-methoxy-5-methyl-benzofuran
CAS No.:310898-68-1
Molecular Formula:C₂₃H₂₀O₃
Molecular Weight:344.41
Hs Code.:

Synonyms:3-(2-benzyloxy-phenyl)-2-methoxy-5-methyl-benzofuran

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Chemical Property of 3-(2-benzyloxy-phenyl)-2-methoxy-5-methyl-benzofuran

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Technology Process of 3-(2-benzyloxy-phenyl)-2-methoxy-5-methyl-benzofuran

There total 11 articles about 3-(2-benzyloxy-phenyl)-2-methoxy-5-methyl-benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 420-37-1
trimethoxonium tetrafluoroborate

: 310898-66-9
3-(2-benzyloxy-phenyl)-5-methyl-3H-benzofuran-2-one

: 310898-68-1
3-(2-benzyloxy-phenyl)-2-methoxy-5-methyl-benzofuran

: 3-(2-benzyloxy-phenyl)-3,5-dimethyl-3H-benzofuran-2-one

Guidance literature:: 3-(2-benzyloxy-phenyl)-5-methyl-3H-benzofuran-2-one; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 1h;

trimethoxonium tetrafluoroborate; In tetrahydrofuran; at 20 ℃; for 2h; Further stages.;
DOI:10.1021/ol006578v

Reference yield:

: 106-44-5
p-cresol

: 310898-68-1
3-(2-benzyloxy-phenyl)-2-methoxy-5-methyl-benzofuran

Guidance literature:: Multi-step reaction with 6 steps

1.1: 36.2 g / K₂CO₃ / acetone / 12 h / Heating

2.1: 78 percent / N,N-dimethylaniline / 16 h / Heating

3.1: O₃ / methanol / 0.75 h / -78 °C

3.2: 66 percent / DMS / methanol / 12 h / 20 °C

4.1: 90 percent / p-TsOH / benzene / 3 h / Heating

5.1: 62 percent / AcOOH / CH₂Cl₂ / 16 h

6.1: NaH / tetrahydrofuran; various solvent(s) / 1 h / 0 °C

6.2: 58 percent / tetrahydrofuran; various solvent(s) / 2 h / 20 °C

With peracetic acid; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; ozone; N,N-dimethyl-aniline; In tetrahydrofuran; methanol; dichloromethane; acetone; benzene; 2.1: Claisen rearrangement;
DOI:10.1021/ol006578v

Reference yield:

: 6236-69-7
methyl 2-hydroxycinnamate

: 310898-68-1
3-(2-benzyloxy-phenyl)-2-methoxy-5-methyl-benzofuran

Guidance literature:: Multi-step reaction with 9 steps

1.1: K₂CO₃ / acetone / 12 h / Heating

2.1: 34.0 g / DIBAL / tetrahydrofuran / 0.5 h / -78 °C

3.1: PBr₃; pyridine / diethyl ether / 2 h / -15 °C

4.1: 36.2 g / K₂CO₃ / acetone / 12 h / Heating

5.1: 78 percent / N,N-dimethylaniline / 16 h / Heating

6.1: O₃ / methanol / 0.75 h / -78 °C

6.2: 66 percent / DMS / methanol / 12 h / 20 °C

7.1: 90 percent / p-TsOH / benzene / 3 h / Heating

8.1: 62 percent / AcOOH / CH₂Cl₂ / 16 h

9.1: NaH / tetrahydrofuran; various solvent(s) / 1 h / 0 °C

9.2: 58 percent / tetrahydrofuran; various solvent(s) / 2 h / 20 °C

With pyridine; peracetic acid; phosphorus tribromide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; ozone; N,N-dimethyl-aniline; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetone; benzene; 5.1: Claisen rearrangement;
DOI:10.1021/ol006578v