3-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydroquinolin-6-carboxylic acid

Base Information

Chemical Name:3-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydroquinolin-6-carboxylic acid
CAS No.:1429438-81-2
Molecular Formula:C₁₉H₁₇NO₅
Molecular Weight:339.348
Hs Code.:

Synonyms:3-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydroquinolin-6-carboxylic acid

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Chemical Property of 3-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydroquinolin-6-carboxylic acid

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Technology Process of 3-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydroquinolin-6-carboxylic acid

There total 6 articles about 3-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydroquinolin-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.4%

: 1429438-80-1
ethyl 3-hydroxy-1-methyl-4-oxo-1,4-dihydroquinolin-6-carboxylate

: 824-94-2
p-methoxybenzyl chloride

: 1429438-81-2
3-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydroquinolin-6-carboxylic acid

Guidance literature:: ethyl 3-hydroxy-1-methyl-4-oxo-1,4-dihydroquinolin-6-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h; Inert atmosphere;

p-methoxybenzyl chloride; In N,N-dimethyl-formamide; at 75 ℃; for 2h; Inert atmosphere;

With water; lithium hydroxide; In methanol; N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield:

: C₁₅H₁₅NO₅

: 1429438-81-2
3-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydroquinolin-6-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 65 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere

2.2: 2 h / 75 °C / Inert atmosphere

2.3: 20 °C / Inert atmosphere

With methanol; sodium hydride; In N,N-dimethyl-formamide;

Reference yield:

: 857559-56-9
ethyl 4-((2-(ethoxycarbonyl)-3-oxobut-1-en-1-yl)amino)benzoate

: 1429438-81-2
3-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydroquinolin-6-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: diphenylether / 0.5 h / 200 - 250 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.1: methanol / 65 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere

5.2: 2 h / 75 °C / Inert atmosphere

5.3: 20 °C / Inert atmosphere

With methanol; diphenylether; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;