2-Acetylamino-2-(4-trifluoromethyl-benzyl)-malonic acid monoethyl ester

Base Information

Chemical Name:2-Acetylamino-2-(4-trifluoromethyl-benzyl)-malonic acid monoethyl ester
CAS No.:153181-04-5
Molecular Formula:C₁₅H₁₆F₃NO₅
Molecular Weight:347.291
Hs Code.:

Synonyms:2-Acetylamino-2-(4-trifluoromethyl-benzyl)-malonic acid monoethyl ester

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Chemical Property of 2-Acetylamino-2-(4-trifluoromethyl-benzyl)-malonic acid monoethyl ester

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Technology Process of 2-Acetylamino-2-(4-trifluoromethyl-benzyl)-malonic acid monoethyl ester

There total 2 articles about 2-Acetylamino-2-(4-trifluoromethyl-benzyl)-malonic acid monoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 114872-59-2
diethyl 2-acetamido-2-<<4-(trifluoromethyl)phenyl>methyl>malonate

: 153181-04-5
2-Acetylamino-2-(4-trifluoromethyl-benzyl)-malonic acid monoethyl ester

Guidance literature:: With sodium hydroxide; In ethanol; for 0.666667h; Ambient temperature;
DOI:10.1016/S0957-4166(00)80371-7

Reference yield:

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 153181-04-5
2-Acetylamino-2-(4-trifluoromethyl-benzyl)-malonic acid monoethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) EtONa / 1.) EtOH, RT, 10 min, 2.) EtOH, reflux, 15 h

2: 85 percent / 3.9 M aq. NaOH / ethanol / 0.67 h / Ambient temperature

With sodium hydroxide; sodium ethanolate; In ethanol;
DOI:10.1016/S0957-4166(00)80371-7