methyl 4-[1-[3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinyl]methylthiobenzoate

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Chemical Name:methyl 4-[1-[3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinyl]methylthiobenzoate
CAS No.:922529-26-8
Molecular Formula:C₃₀H₃₃N₃O₅S
Molecular Weight:547.675
Hs Code.:

Synonyms:methyl 4-[1-[3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinyl]methylthiobenzoate

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Chemical Property of methyl 4-[1-[3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinyl]methylthiobenzoate

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Technology Process of methyl 4-[1-[3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinyl]methylthiobenzoate

There total 5 articles about methyl 4-[1-[3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinyl]methylthiobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 922529-25-7
methyl 4-[(2S)-pyrrolidinyl]methylthiobenzoate

: pentafluorophenyl 3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetate

: 922529-26-8
methyl 4-[1-[3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinyl]methylthiobenzoate

Guidance literature:: With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1248/cpb.54.1515

Reference yield:

: 922529-41-7
1-(tert-butoxycarbonyl)-(2S)-pyrrolidinylmethyl 4-iodophenyl sulfide

: 922529-26-8
methyl 4-[1-[3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinyl]methylthiobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / Pd(OAc)2; 1,3-bis(diphenylphosphino)propane / dimethylsulfoxide / 12 h / 70 °C

2: 92 percent / TFA / CH₂Cl₂ / 1.5 h / 20 °C

3: 82 percent / EDC*HCl; HOBt; DMAP / dimethylformamide / 12 h / 20 °C

With dmap; palladium diacetate; 1,3-bis-(diphenylphosphino)propane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.54.1515

Reference yield:

: 922529-42-8
methyl 4-[1-(tert-butoxycarbonyl)-(2S)-pyrrolidinyl]methylthiobenzoate

: 922529-26-8
methyl 4-[1-[3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinyl]methylthiobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / TFA / CH₂Cl₂ / 1.5 h / 20 °C

2: 82 percent / EDC*HCl; HOBt; DMAP / dimethylformamide / 12 h / 20 °C

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.54.1515