S-(R)-2-acetamidoethyl 3-(2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propanamido)-2,2-dimethylpropanethioate

Base Information

Chemical Name:S-(R)-2-acetamidoethyl 3-(2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propanamido)-2,2-dimethylpropanethioate
CAS No.:1333123-46-8
Molecular Formula:C₂₄H₃₆ClN₃O₆S
Molecular Weight:530.085
Hs Code.:

Synonyms:S-(R)-2-acetamidoethyl 3-(2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propanamido)-2,2-dimethylpropanethioate

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Chemical Property of S-(R)-2-acetamidoethyl 3-(2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propanamido)-2,2-dimethylpropanethioate

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Technology Process of S-(R)-2-acetamidoethyl 3-(2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propanamido)-2,2-dimethylpropanethioate

There total 2 articles about S-(R)-2-acetamidoethyl 3-(2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propanamido)-2,2-dimethylpropanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1333123-43-5
2-acetamidoethyl 3-(tert-butoxycarbonylamino)-2,2-dimethylpropanethioate

: 162465-45-4
(R)-2-((tet-butoxycarbonyl)amino)-3-(3-chloro-4-methoxyphenyl)propanoic acid

: 1333123-46-8
S-(R)-2-acetamidoethyl 3-(2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propanamido)-2,2-dimethylpropanethioate

Guidance literature:: 2-acetamidoethyl 3-(tert-butoxycarbonylamino)-2,2-dimethylpropanethioate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

(R)-2-((tet-butoxycarbonyl)amino)-3-(3-chloro-4-methoxyphenyl)propanoic acid; With dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/ja204716f

Reference yield:

: 180181-02-6
3-(tert-Butoxycarbonyl)amino-2,2-dimethylpropanoic Acid

: 1333123-46-8
S-(R)-2-acetamidoethyl 3-(2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propanamido)-2,2-dimethylpropanethioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2.2: 18 h / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ja204716f

Reference yield: 8.0%

: 869195-52-8
(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenylocta-2,7-dienoic acid

: 1333123-46-8
S-(R)-2-acetamidoethyl 3-(2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propanamido)-2,2-dimethylpropanethioate

: 1333123-38-8
S-2-acetamidoethyl 3-((R)-3-(3-chloro-4-methoxyphenyl)-2-((2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenylocta-2,7-dienamido)propanamido)-2,2-dimethylpropanethioate

Guidance literature:: S-(R)-2-acetamidoethyl 3-(2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propanamido)-2,2-dimethylpropanethioate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenylocta-2,7-dienoic acid; With dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/ja204716f