(3'R,5'R)-3'5'-bis[(tert-butyldimethylsilyl)oxy]-(20S)-20-al-2-methylene-19-nor-pregnacalciferol

Base Information

Chemical Name:(3'R,5'R)-3'5'-bis[(tert-butyldimethylsilyl)oxy]-(20S)-20-al-2-methylene-19-nor-pregnacalciferol
CAS No.:845815-90-9
Molecular Formula:C₃₄H₆₀O₃Si₂
Molecular Weight:573.02
Hs Code.:

Synonyms:(3'R,5'R)-3'5'-bis[(tert-butyldimethylsilyl)oxy]-(20S)-20-al-2-methylene-19-nor-pregnacalciferol

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Chemical Property of (3'R,5'R)-3'5'-bis[(tert-butyldimethylsilyl)oxy]-(20S)-20-al-2-methylene-19-nor-pregnacalciferol

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Technology Process of (3'R,5'R)-3'5'-bis[(tert-butyldimethylsilyl)oxy]-(20S)-20-al-2-methylene-19-nor-pregnacalciferol

There total 3 articles about (3'R,5'R)-3'5'-bis[(tert-butyldimethylsilyl)oxy]-(20S)-20-al-2-methylene-19-nor-pregnacalciferol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 610304-70-6
C₄₁H₆₈O₅SSi₂

: 845815-90-9
(3'R,5'R)-3'5'-bis[(tert-butyldimethylsilyl)oxy]-(20S)-20-al-2-methylene-19-nor-pregnacalciferol

Guidance literature:: With sodium hydrogencarbonate; dimethyl sulfoxide;
DOI:10.1021/jm100649d

Reference yield:

: 610304-69-3
(S)-2-((1R,3αS,7αR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-4-methylenecyclohexylidene)ethylidene)-7α-methyloctahydro-1H-inden-1-yl)propan-1-ol

: 845815-90-9
(3'R,5'R)-3'5'-bis[(tert-butyldimethylsilyl)oxy]-(20S)-20-al-2-methylene-19-nor-pregnacalciferol

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.166667h;

(S)-2-((1R,3αS,7αR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-4-methylenecyclohexylidene)ethylidene)-7α-methyloctahydro-1H-inden-1-yl)propan-1-ol; In dichloromethane; at -78 ℃; for 0.5h;

With triethylamine; In dichloromethane; at -78 ℃;

Reference yield:

: 845815-90-9
(3'R,5'R)-3'5'-bis[(tert-butyldimethylsilyl)oxy]-(20S)-20-al-2-methylene-19-nor-pregnacalciferol

Guidance literature:: With sodium methylate; In methanol;

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -60 ℃;