(L)-5’-O-(t-butyldiphenylsilyl)-2’,3-dideoxy-2’-fluoro-5-fluorocytidine

Base Information

Chemical Name:(L)-5’-O-(t-butyldiphenylsilyl)-2’,3-dideoxy-2’-fluoro-5-fluorocytidine
CAS No.:202272-32-0
Molecular Formula:C₂₅H₂₉F₂N₃O₃Si
Molecular Weight:485.606
Hs Code.:

Synonyms:(L)-5’-O-(t-butyldiphenylsilyl)-2’,3-dideoxy-2’-fluoro-5-fluorocytidine

Suppliers and Price of (L)-5’-O-(t-butyldiphenylsilyl)-2’,3-dideoxy-2’-fluoro-5-fluorocytidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (L)-5’-O-(t-butyldiphenylsilyl)-2’,3-dideoxy-2’-fluoro-5-fluorocytidine

Chemical Property:

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Technology Process of (L)-5’-O-(t-butyldiphenylsilyl)-2’,3-dideoxy-2’-fluoro-5-fluorocytidine

There total 6 articles about (L)-5’-O-(t-butyldiphenylsilyl)-2’,3-dideoxy-2’-fluoro-5-fluorocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 2022-85-7
Flucytosine

: 202272-29-5
1-O-acetyl-5-O-(t-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-(L)-erythron-pentofuranose

: 202272-32-0
(L)-5’-O-(t-butyldiphenylsilyl)-2’,3-dideoxy-2’-fluoro-5-fluorocytidine

Guidance literature:: Flucytosine; With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; for 1h;

1-O-acetyl-5-O-(t-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-(L)-erythron-pentofuranose; With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 20 ℃; for 4h; Inert atmosphere;

Reference yield: 99.0%

: C₂₂H₂₇FO₄Si

: 111878-21-8
2-trimethylsilyloxy-4-trimethylsilylamino-5-fluoropyrimidine

: 202272-32-0
(L)-5’-O-(t-butyldiphenylsilyl)-2’,3-dideoxy-2’-fluoro-5-fluorocytidine

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate;

Reference yield:

: 128075-94-5
(R)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}dihydrofuran-2(3H)-one

: 202272-32-0
(L)-5’-O-(t-butyldiphenylsilyl)-2’,3-dideoxy-2’-fluoro-5-fluorocytidine

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / N-fluorodibenzenesulfonimide, LiHMDS / tetrahydrofuran / 3 h / -78 °C

2: 98 percent / DIBALH / tetrahydrofuran; hexane / 3 h / -78 °C

3: 99 percent / DMAP / CH₂Cl₂ / Ambient temperature

4: 1.51 g / TMS triflate / 1,2-dichloro-ethane / 4 h / Ambient temperature

With dmap; trimethylsilyl trifluoromethanesulfonate; diisobutylaluminium hydride; N-fluorobis(benzenesulfon)imide; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jo9717898