2-(3-chloroisoxazol-5-yl)-5-(2-trifluoromethylphenyl)-1H-benzimidazole

Base Information

Chemical Name:2-(3-chloroisoxazol-5-yl)-5-(2-trifluoromethylphenyl)-1H-benzimidazole
CAS No.:1392517-45-1
Molecular Formula:C₁₇H₉ClF₃N₃O
Molecular Weight:363.726
Hs Code.:

Synonyms:2-(3-chloroisoxazol-5-yl)-5-(2-trifluoromethylphenyl)-1H-benzimidazole

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Chemical Property of 2-(3-chloroisoxazol-5-yl)-5-(2-trifluoromethylphenyl)-1H-benzimidazole

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Technology Process of 2-(3-chloroisoxazol-5-yl)-5-(2-trifluoromethylphenyl)-1H-benzimidazole

There total 2 articles about 2-(3-chloroisoxazol-5-yl)-5-(2-trifluoromethylphenyl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 471240-43-4
2'-(trifluoromethyl)-[1,1'-biphenyl]-3,4-diamine

: 104164-45-6
3-chloro-5-isoxazolecarboxylic acid chloride

: 1392517-45-1
2-(3-chloroisoxazol-5-yl)-5-(2-trifluoromethylphenyl)-1H-benzimidazole

Guidance literature:: 2'-(trifluoromethyl)-[1,1'-biphenyl]-3,4-diamine; 3-chloro-5-isoxazolecarboxylic acid chloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 16h;

With p-toluenesulfonic acid monohydrate; In 1,4-dioxane; at 100 ℃; for 6h;

With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; pH=10;

Reference yield:

: 1392517-44-0
(3-tert-Butoxycarbonylamino-2'-trifluoromethylbiphenyl-4-yl)-carbamic acid tert-butyl ester

: 1392517-45-1
2-(3-chloroisoxazol-5-yl)-5-(2-trifluoromethylphenyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

1.2: Saturated solution

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 20 °C

2.2: 6 h / 100 °C

2.3: 20 °C / pH 10

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;