N,N′-(2-((2-(bis(4-methoxybenzyl)amino)-4,6-diethoxypyrimidin-5-yl)thio)pyrimidine-4,6-diyl)diacetamide

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Chemical Name:N,N′-(2-((2-(bis(4-methoxybenzyl)amino)-4,6-diethoxypyrimidin-5-yl)thio)pyrimidine-4,6-diyl)diacetamide
CAS No.:1268273-28-4
Molecular Formula:C₃₂H₃₇N₇O₆S
Molecular Weight:647.755
Hs Code.:

Synonyms:N,N′-(2-((2-(bis(4-methoxybenzyl)amino)-4,6-diethoxypyrimidin-5-yl)thio)pyrimidine-4,6-diyl)diacetamide

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Chemical Property of N,N′-(2-((2-(bis(4-methoxybenzyl)amino)-4,6-diethoxypyrimidin-5-yl)thio)pyrimidine-4,6-diyl)diacetamide

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Technology Process of N,N′-(2-((2-(bis(4-methoxybenzyl)amino)-4,6-diethoxypyrimidin-5-yl)thio)pyrimidine-4,6-diyl)diacetamide

There total 4 articles about N,N′-(2-((2-(bis(4-methoxybenzyl)amino)-4,6-diethoxypyrimidin-5-yl)thio)pyrimidine-4,6-diyl)diacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1268273-27-3
2-((2-(bis(4-methoxybenzyl)amino)-4,6-diethoxypyrimidin-5-yl)thio)pyrimidine-4,6-diamine

: 108-24-7
acetic anhydride

: 1268273-28-4
N,N′-(2-((2-(bis(4-methoxybenzyl)amino)-4,6-diethoxypyrimidin-5-yl)thio)pyrimidine-4,6-diyl)diacetamide

Guidance literature:: dmap; at 110 ℃; for 2h; Inert atmosphere;

Reference yield:

: 90154-00-0
2-Amino-4,6-diethoxy-pyrimidin

: 1268273-28-4
N,N′-(2-((2-(bis(4-methoxybenzyl)amino)-4,6-diethoxypyrimidin-5-yl)thio)pyrimidine-4,6-diyl)diacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

1.2: 20 °C

2.1: N-iodo-succinimide / acetonitrile / 1 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline / dimethyl sulfoxide / 16 h / 120 °C / Inert atmosphere

4.1: dmap / 2 h / 110 °C / Inert atmosphere

With N-iodo-succinimide; sodium hydride; potassium carbonate; dmap; copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline; In dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1268273-25-1
4,6-diethoxy-N,N-bis(4-methoxybenzyl)pyrimidin-2-amine

: 1268273-28-4
N,N′-(2-((2-(bis(4-methoxybenzyl)amino)-4,6-diethoxypyrimidin-5-yl)thio)pyrimidine-4,6-diyl)diacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodo-succinimide / acetonitrile / 1 h / 20 °C / Inert atmosphere

2: potassium carbonate / copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline / dimethyl sulfoxide / 16 h / 120 °C / Inert atmosphere

3: dmap / 2 h / 110 °C / Inert atmosphere

With N-iodo-succinimide; potassium carbonate; dmap; copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline; In dimethyl sulfoxide; acetonitrile;