C₄₉H₅₂N₈O₇

Base Information

• Chemical Name: C₄₉H₅₂N₈O₇
• CAS No.: 1357258-61-7
• Molecular Formula: C₄₉H₅₂N₈O₇
• Molecular Weight: 865.001
• Mol file: 1357258-61-7.mol

Synonyms:C₄₉H₅₂N₈O₇

Chemical Property of C₄₉H₅₂N₈O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₉H₅₂N₈O₇

There total 18 articles about C₄₉H₅₂N₈O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C44H46N8O5*(x)ClH + cyclobutyl 2,5-dioxopyrrolidin-1-yl carbonate (128595-06-2) → C49H52N8O7 (1357258-61-7)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water; at 10 ℃; for 1h;

Reference yield:

N-methoxycarbonyl-L-valine (111398-44-8,74761-42-5) → C49H52N8O7 (1357258-61-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 1 h / 10 °C

1.2: 48 h / 0 - 10 °C

2.1: triethylamine; hydrogen / 10 wt% Pd(OH)2 on carbon / methanol / 3 h / 10 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 0 - 10 °C

4.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 1 h / 10 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 0 °C

6.1: sodium hydrogencarbonate / water; tetrahydrofuran / 1 h / 10 °C

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

N-Benzyloxycarbonyl-L-proline (1148-11-4) → C49H52N8O7 (1357258-61-7)

Guidance literature:

Multi-step reaction with 11 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

2.1: sodium hydroxide / water; tetrahydrofuran / 1 h / 20 °C

3.1: potassium hydroxide / ethanol; water / 3 h / 80 °C

3.2: 0 °C / pH 7

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 10 h / 90 °C / Inert atmosphere

4.2: pH 10

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 1 h / 10 °C

6.2: 48 h / 0 - 10 °C

7.1: triethylamine; hydrogen / 10 wt% Pd(OH)2 on carbon / methanol / 3 h / 10 °C

8.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 0 - 10 °C

9.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 1 h / 10 °C

10.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 0 °C

11.1: sodium hydrogencarbonate / water; tetrahydrofuran / 1 h / 10 °C

With hydrogenchloride; oxalyl dichloride; hydrogen; sodium hydrogencarbonate; sodium carbonate; benzotriazol-1-ol; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

upstream raw materials:

N-methoxycarbonyl-L-valine

L-valine

2-amino-4-bromo-benzoic acid methyl ester

N-Benzyloxycarbonyl-L-proline