(R)-3-((S)-2-Amino-4-methyl-pentanoylamino)-4-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-butyric acid; compound with trifluoro-acetic acid

Base Information

Chemical Name:(R)-3-((S)-2-Amino-4-methyl-pentanoylamino)-4-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-butyric acid; compound with trifluoro-acetic acid
CAS No.:118248-04-7
Molecular Formula:C₂HF₃O₂*C₂₀H₃₀N₄O₅
Molecular Weight:520.506
Hs Code.:

Synonyms:(R)-3-((S)-2-Amino-4-methyl-pentanoylamino)-4-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-butyric acid; compound with trifluoro-acetic acid

Suppliers and Price of (R)-3-((S)-2-Amino-4-methyl-pentanoylamino)-4-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-butyric acid; compound with trifluoro-acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-3-((S)-2-Amino-4-methyl-pentanoylamino)-4-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-butyric acid; compound with trifluoro-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-3-((S)-2-Amino-4-methyl-pentanoylamino)-4-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-butyric acid; compound with trifluoro-acetic acid

There total 6 articles about (R)-3-((S)-2-Amino-4-methyl-pentanoylamino)-4-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-butyric acid; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83436-45-7
(3R)-3-benzyloxycarbonylamino-4-tert-butyoxycarbonylbutyric acid

: 118248-04-7
(R)-3-((S)-2-Amino-4-methyl-pentanoylamino)-4-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-butyric acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 2 h / 0 °C

2: 75 percent / dimethylformamide / 3 h / Ambient temperature

3: hydrogen / 10 percent Pd/C / ethanol; acetic acid / 5 h / 760 Torr / Ambient temperature

4: diisopropylethylamine / dimethylformamide / 1 h / Ambient temperature

5: 0.5 h / Ambient temperature

With hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00123a003

Reference yield:

: 83436-44-6
Z-β-homo-Asp(OBut)-OMe

: 118248-04-7
(R)-3-((S)-2-Amino-4-methyl-pentanoylamino)-4-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-butyric acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 2 N NaOH / methanol / 0.5 h / 30 °C

2: 72 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 2 h / 0 °C

3: 75 percent / dimethylformamide / 3 h / Ambient temperature

4: hydrogen / 10 percent Pd/C / ethanol; acetic acid / 5 h / 760 Torr / Ambient temperature

5: diisopropylethylamine / dimethylformamide / 1 h / Ambient temperature

6: 0.5 h / Ambient temperature

With sodium hydroxide; hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00123a003

Reference yield:

: 118248-02-5
Z-Asp(OBut)-CHN₂

: 118248-04-7
(R)-3-((S)-2-Amino-4-methyl-pentanoylamino)-4-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-butyric acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: silver benzoate, triethylamine / 30 h / Ambient temperature

2: 2 N NaOH / methanol / 0.5 h / 30 °C

3: 72 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 2 h / 0 °C

4: 75 percent / dimethylformamide / 3 h / Ambient temperature

5: hydrogen / 10 percent Pd/C / ethanol; acetic acid / 5 h / 760 Torr / Ambient temperature

6: diisopropylethylamine / dimethylformamide / 1 h / Ambient temperature

7: 0.5 h / Ambient temperature

With sodium hydroxide; hydrogen; silver benzoate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00123a003