N-(3-bromo-phenyl)-N'-{3-methyl-4-[(6-butoxy-7-[2-(diethylaminoe)thoxy]quinazolin-4-yl)oxy]phenyl}urea

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Chemical Name:N-(3-bromo-phenyl)-N'-{3-methyl-4-[(6-butoxy-7-[2-(diethylaminoe)thoxy]quinazolin-4-yl)oxy]phenyl}urea
CAS No.:1609458-54-9
Molecular Formula:C₃₂H₃₈BrN₅O₄
Molecular Weight:636.589
Hs Code.:

Synonyms:N-(3-bromo-phenyl)-N'-{3-methyl-4-[(6-butoxy-7-[2-(diethylaminoe)thoxy]quinazolin-4-yl)oxy]phenyl}urea

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Chemical Property of N-(3-bromo-phenyl)-N'-{3-methyl-4-[(6-butoxy-7-[2-(diethylaminoe)thoxy]quinazolin-4-yl)oxy]phenyl}urea

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Technology Process of N-(3-bromo-phenyl)-N'-{3-methyl-4-[(6-butoxy-7-[2-(diethylaminoe)thoxy]quinazolin-4-yl)oxy]phenyl}urea

There total 3 articles about N-(3-bromo-phenyl)-N'-{3-methyl-4-[(6-butoxy-7-[2-(diethylaminoe)thoxy]quinazolin-4-yl)oxy]phenyl}urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1609458-51-6
N-(3-bromophenyl)-N'-(2-methyl-4-hydroxyphenyl)urea

: 1352785-95-5
C₁₈H₂₆ClN₃O₂

: 1609458-54-9
N-(3-bromo-phenyl)-N'-{3-methyl-4-[(6-butoxy-7-[2-(diethylaminoe)thoxy]quinazolin-4-yl)oxy]phenyl}urea

Guidance literature:: With tetrabutylammomium bromide; sodium hydroxide; In butanone; at 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2014.04.007

Reference yield:

: 23138-55-8
3-Bromophenyl isocyanate

: 1609458-54-9
N-(3-bromo-phenyl)-N'-{3-methyl-4-[(6-butoxy-7-[2-(diethylaminoe)thoxy]quinazolin-4-yl)oxy]phenyl}urea

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 1 h / 20 °C / Inert atmosphere

2: tetrabutylammomium bromide; sodium hydroxide / butanone / 1 h / 20 °C

With pyridine; tetrabutylammomium bromide; sodium hydroxide; In butanone;
DOI:10.1016/j.ejmech.2014.04.007

Reference yield:

: 2835-99-6
4-amino-3-methylphenol

: 1609458-54-9
N-(3-bromo-phenyl)-N'-{3-methyl-4-[(6-butoxy-7-[2-(diethylaminoe)thoxy]quinazolin-4-yl)oxy]phenyl}urea

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 1 h / 20 °C / Inert atmosphere

2: tetrabutylammomium bromide; sodium hydroxide / butanone / 1 h / 20 °C

With pyridine; tetrabutylammomium bromide; sodium hydroxide; In butanone;
DOI:10.1016/j.ejmech.2014.04.007