5'-O-(4,4'-dimethoxytrityl)-N²-palmitoyl-2'-phthalimido-2'-deoxyguanosine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-N²-palmitoyl-2'-phthalimido-2'-deoxyguanosine
• CAS No.: 874443-90-0
• Molecular Formula: C₅₅H₆₄N₆O₉
• Molecular Weight: 953.148

Synonyms:5'-O-(4,4'-dimethoxytrityl)-N²-palmitoyl-2'-phthalimido-2'-deoxyguanosine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-N²-palmitoyl-2'-phthalimido-2'-deoxyguanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(4,4'-dimethoxytrityl)-N²-palmitoyl-2'-phthalimido-2'-deoxyguanosine

There total 5 articles about 5'-O-(4,4'-dimethoxytrityl)-N²-palmitoyl-2'-phthalimido-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

9-(N2-palmitoyl-2'-phthalimido-2'-deoxy-β-D-ribofuranosyl)guanine (874443-86-4) + 4,4'-dimethoxytrityl chloride (40615-36-9) → 5'-O-(4,4'-dimethoxytrityl)-N2-palmitoyl-2'-phthalimido-2'-deoxyguanosine (874443-90-0)

Guidance literature:

With pyridine; at 20 ℃;

DOI:10.1016/j.bmc.2005.08.050

Reference yield:

N-ethoxycarbonylphthalimide (22509-74-6) → 5'-O-(4,4'-dimethoxytrityl)-N2-palmitoyl-2'-phthalimido-2'-deoxyguanosine (874443-90-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 20 °C

1.2: MeOH; Et₃N / tetrahydrofuran / 1 h

2.1: 747 mg / trichloroacetic acid / acetonitrile / 1 h

3.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 0.5 h / Heating

3.2: trimethylsilyl triflate / acetonitrile / 3 h / Heating

3.3: 60 percent / HCl / acetonitrile; H₂O

4.1: 82 percent / pyridine / 20 °C

With pyridine; N,O-bis-(trimethylsilyl)-acetamide; trichloroacetic acid; In tetrahydrofuran; acetonitrile;

DOI:10.1016/j.bmc.2005.08.050

Reference yield:

5'-O-dimethoxytrityl-2'-amino-2'-deoxyuridine (174221-86-4) → 5'-O-(4,4'-dimethoxytrityl)-N2-palmitoyl-2'-phthalimido-2'-deoxyguanosine (874443-90-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 20 °C

1.2: MeOH; Et₃N / tetrahydrofuran / 1 h

2.1: 747 mg / trichloroacetic acid / acetonitrile / 1 h

3.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 0.5 h / Heating

3.2: trimethylsilyl triflate / acetonitrile / 3 h / Heating

3.3: 60 percent / HCl / acetonitrile; H₂O

4.1: 82 percent / pyridine / 20 °C

With pyridine; N,O-bis-(trimethylsilyl)-acetamide; trichloroacetic acid; In tetrahydrofuran; acetonitrile;

DOI:10.1016/j.bmc.2005.08.050

upstream raw materials:

9-(N²-palmitoyl-2'-phthalimido-2'-deoxy-β-D-ribofuranosyl)guanine

4,4'-dimethoxytrityl chloride

N-ethoxycarbonylphthalimide

5'-O-dimethoxytrityl-2'-amino-2'-deoxyuridine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 874443-90-0 5'-O-(4,4'-dimethoxytrityl)-N²-palmitoyl-2'-phthalimido-2'-deoxyguanosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send