(2R)-1,4-anhydro-3,5-di-O-benzyl-2-deoxy-2--D-arabitol

Base Information

Chemical Name:(2R)-1,4-anhydro-3,5-di-O-benzyl-2-deoxy-2--D-arabitol
CAS No.:161452-69-3
Molecular Formula:C₂₅H₃₀N₂O₆
Molecular Weight:454.523
Hs Code.:

(2R)-1,4-anhydro-3,5-di-O-benzyl-2-deoxy-2-<N-(3-ethoxyacryloyl)ureido>-D-arabitol

Synonyms:(2R)-1,4-anhydro-3,5-di-O-benzyl-2-deoxy-2--D-arabitol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-1,4-anhydro-3,5-di-O-benzyl-2-deoxy-2--D-arabitol

Chemical Property:

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Technology Process of (2R)-1,4-anhydro-3,5-di-O-benzyl-2-deoxy-2--D-arabitol

There total 13 articles about (2R)-1,4-anhydro-3,5-di-O-benzyl-2-deoxy-2--D-arabitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 115983-78-3,928778-13-6
(E)-3-ethoxypropenoyl isocyanate

: 161452-67-1
(2R)-2-amino-1,4-anhydro-3,5-di-O-benzyl-2-deoxy-D-arabitol

: 161452-69-3
(2R)-1,4-anhydro-3,5-di-O-benzyl-2-deoxy-2--D-arabitol

Guidance literature:: In N,N-dimethyl-formamide; benzene; 1.) -18 deg C, 1 h; 2.) RT, 1 h;
DOI:10.1016/S0040-4020(01)81749-X

Reference yield:

: 37077-81-9
1,2-isopropylidene-α-D-ribofuranose

: 161452-69-3
(2R)-1,4-anhydro-3,5-di-O-benzyl-2-deoxy-2--D-arabitol

Guidance literature:: Multi-step reaction with 6 steps

1: NaH / dimethylformamide / 13.5 h / Ambient temperature

2: 75 percent / trimethylsilyl trifluoromethanesulfonate (TMSOTf), Et₃SiH / CH₂Cl₂ / 18.5 h / Ambient temperature

3: 97 percent / DMAP, Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

4: 90 percent / LiN₃ / dimethylformamide / 6 h / 100 °C

5: 95 percent / H₂ / Lindlar catalyst / methanol; ethyl acetate / 6 h / Ambient temperature

6: 96 percent / benzene; dimethylformamide / 1.) -18 deg C, 1 h; 2.) RT, 1 h

With triethylsilane; dmap; lithium azide; trimethylsilyl trifluoromethanesulfonate; hydrogen; sodium hydride; triethylamine; Lindlar's catalyst; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(01)81749-X

Reference yield:

: 55735-86-9
3,5-O-dibenzyloxy-1,2-O-isorpopylidene-α-D-ribofuranose

: 161452-69-3
(2R)-1,4-anhydro-3,5-di-O-benzyl-2-deoxy-2--D-arabitol

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / trimethylsilyl trifluoromethanesulfonate (TMSOTf), Et₃SiH / CH₂Cl₂ / 18.5 h / Ambient temperature

2: 97 percent / DMAP, Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

3: 90 percent / LiN₃ / dimethylformamide / 6 h / 100 °C

4: 95 percent / H₂ / Lindlar catalyst / methanol; ethyl acetate / 6 h / Ambient temperature

5: 96 percent / benzene; dimethylformamide / 1.) -18 deg C, 1 h; 2.) RT, 1 h

With triethylsilane; dmap; lithium azide; trimethylsilyl trifluoromethanesulfonate; hydrogen; triethylamine; Lindlar's catalyst; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(01)81749-X