N-(4-(4-(3-cyclopropyl-3-fluoroazetidin-1-yl)-6-(pyridin-2-ylamino)pyrimidin-2-ylthio)phenyl)-3,3,3-trifluoropropanamide

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Chemical Name:N-(4-(4-(3-cyclopropyl-3-fluoroazetidin-1-yl)-6-(pyridin-2-ylamino)pyrimidin-2-ylthio)phenyl)-3,3,3-trifluoropropanamide
CAS No.:1079394-16-3
Molecular Formula:C₂₄H₂₂F₄N₆OS
Molecular Weight:518.538
Hs Code.:

Synonyms:N-(4-(4-(3-cyclopropyl-3-fluoroazetidin-1-yl)-6-(pyridin-2-ylamino)pyrimidin-2-ylthio)phenyl)-3,3,3-trifluoropropanamide

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Chemical Property of N-(4-(4-(3-cyclopropyl-3-fluoroazetidin-1-yl)-6-(pyridin-2-ylamino)pyrimidin-2-ylthio)phenyl)-3,3,3-trifluoropropanamide

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Technology Process of N-(4-(4-(3-cyclopropyl-3-fluoroazetidin-1-yl)-6-(pyridin-2-ylamino)pyrimidin-2-ylthio)phenyl)-3,3,3-trifluoropropanamide

There total 3 articles about N-(4-(4-(3-cyclopropyl-3-fluoroazetidin-1-yl)-6-(pyridin-2-ylamino)pyrimidin-2-ylthio)phenyl)-3,3,3-trifluoropropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.8%

: 936548-77-5
3-cyclopropyl-3-fluoroazetidine hydrochloride

: 1079394-25-4
N-(4-(4-chloro-6-(pyridin-2-ylamino)pyrimidin-2-ylthio)phenyl)-3,3,3-trifluoropropanamide

: 1079394-16-3
N-(4-(4-(3-cyclopropyl-3-fluoroazetidin-1-yl)-6-(pyridin-2-ylamino)pyrimidin-2-ylthio)phenyl)-3,3,3-trifluoropropanamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 140 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 936548-80-0
3,3,3-trifluoro-N-(4-mercaptophenyl)propanamide

: 1079394-16-3
N-(4-(4-(3-cyclopropyl-3-fluoroazetidin-1-yl)-6-(pyridin-2-ylamino)pyrimidin-2-ylthio)phenyl)-3,3,3-trifluoropropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / acetonitrile / 0.33 h / -10 - 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium carbonate / 1,4-dioxane / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; acetonitrile;

Reference yield:

: 1061682-23-2
N-(4-(4,6-dichloropyrimidin-2-ylthio)phenyl)-3,3,3-trifluoropropanamide

: 1079394-16-3
N-(4-(4-(3-cyclopropyl-3-fluoroazetidin-1-yl)-6-(pyridin-2-ylamino)pyrimidin-2-ylthio)phenyl)-3,3,3-trifluoropropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium carbonate / 1,4-dioxane / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

2: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane;