ethyl {2-[(2E)-2-(cyclohexylmethylidene)hexanoyl]phenyl}carbamate

Base Information

• Chemical Name: ethyl {2-[(2E)-2-(cyclohexylmethylidene)hexanoyl]phenyl}carbamate
• CAS No.: 1165795-67-4
• Molecular Formula: C₂₂H₃₁NO₃
• Molecular Weight: 357.493
• Mol file: 1165795-67-4.mol

Synonyms:ethyl {2-[(2E)-2-(cyclohexylmethylidene)hexanoyl]phenyl}carbamate

Chemical Property of ethyl {2-[(2E)-2-(cyclohexylmethylidene)hexanoyl]phenyl}carbamate

Chemical Property:

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Technology Process of ethyl {2-[(2E)-2-(cyclohexylmethylidene)hexanoyl]phenyl}carbamate

There total 1 articles about ethyl {2-[(2E)-2-(cyclohexylmethylidene)hexanoyl]phenyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

ethyl N-[2-(1-butynyl)phenyl]carbamate (104919-72-4) + cyclohexanecarbaldehyde (2043-61-0) → ethyl {2-[(2E)-2-(cyclohexylmethylidene)hexanoyl]phenyl}carbamate (1165795-67-4) + rac-(2RS,3RS)-ethyl 3-butyl-2-cyclohexyl-3,4-dihydro-4-oxoquinoline-1(2H)-carboxylate

Guidance literature:

With antimony(V) fluoride pentanmethanolate; In 1,2-dichloro-ethane; at 20 - 40 ℃; Inert atmosphere;

DOI:10.1021/jo900857c

Reference yield: 100.0%

ethyl {2-[(2E)-2-(cyclohexylmethylidene)hexanoyl]phenyl}carbamate (1165795-67-4) → rac-(2RS,3RS)-ethyl 3-butyl-2-cyclohexyl-3,4-dihydro-4-oxoquinoline-1(2H)-carboxylate

Guidance literature:

With antimony(V) fluoride pentanmethanolate; In 1,2-dichloro-ethane; at 90 ℃; for 1h; optical yield given as %de; Inert atmosphere;

DOI:10.1021/jo900857c

upstream raw materials:

ethyl N-[2-(1-butynyl)phenyl]carbamate

cyclohexanecarbaldehyde