(1R,2S)-ethyl 2-phenyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)cyclopropanecarboxylate

Base Information

Chemical Name:(1R,2S)-ethyl 2-phenyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)cyclopropanecarboxylate
CAS No.:1263944-34-8
Molecular Formula:C₂₅H₂₀F₃N₃O₂
Molecular Weight:451.448
Hs Code.:

Synonyms:(1R,2S)-ethyl 2-phenyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)cyclopropanecarboxylate

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Chemical Property of (1R,2S)-ethyl 2-phenyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)cyclopropanecarboxylate

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Technology Process of (1R,2S)-ethyl 2-phenyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)cyclopropanecarboxylate

There total 3 articles about (1R,2S)-ethyl 2-phenyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (trans)-ethyl 2-phenyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)cyclopropanecarboxylate

: 1263944-34-8
(1R,2S)-ethyl 2-phenyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)cyclopropanecarboxylate

: 1264297-02-0
(1S,2R)-ethyl 2-phenyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)cyclopropanecarboxylate

Guidance literature:: ChiralPak AD-H; In hexane; isopropyl alcohol; Resolution of racemate;

Reference yield:

: 72174-84-6
ethyl 1-acetyl-2-phenylcyclopropanecarboxylate

: 1263944-34-8
(1R,2S)-ethyl 2-phenyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)cyclopropanecarboxylate

: 1264297-02-0
(1S,2R)-ethyl 2-phenyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 32 h / 80 - 120 °C

2: acetic acid / ethanol / 16 h / 85 °C

3: ChiralPak AD-H / isopropyl alcohol; hexane / Resolution of racemate

With acetic acid; ChiralPak AD-H; In ethanol; hexane; isopropyl alcohol;

Reference yield:

: 1264296-13-0
ethyl 2-benzylidene-5-(dimethylamino)-3-oxopent-4-enoate

: 1263944-34-8
(1R,2S)-ethyl 2-phenyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)cyclopropanecarboxylate

: 1264297-02-0
(1S,2R)-ethyl 2-phenyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / ethanol / 16 h / 85 °C

2: ChiralPak AD-H / isopropyl alcohol; hexane / Resolution of racemate

With acetic acid; ChiralPak AD-H; In ethanol; hexane; isopropyl alcohol;