4-(4-methoxybenzoyl)-1-methyl-5-hydroxy-3-trifluoromethylpyrazole

Base Information

• Chemical Name: 4-(4-methoxybenzoyl)-1-methyl-5-hydroxy-3-trifluoromethylpyrazole
• CAS No.: 211256-76-7
• Molecular Formula: C₁₃H₁₁F₃N₂O₃
• Molecular Weight: 300.237
• Mol file: 211256-76-7.mol

Synonyms:4-(4-methoxybenzoyl)-1-methyl-5-hydroxy-3-trifluoromethylpyrazole

Chemical Property of 4-(4-methoxybenzoyl)-1-methyl-5-hydroxy-3-trifluoromethylpyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-methoxybenzoyl)-1-methyl-5-hydroxy-3-trifluoromethylpyrazole

There total 3 articles about 4-(4-methoxybenzoyl)-1-methyl-5-hydroxy-3-trifluoromethylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-bromo-5-(4-methoxybenzoyl)oxy-1-methyl-3-trifluoromethylpyrazole (211256-73-4) → 4-(4-methoxybenzoyl)-1-methyl-5-hydroxy-3-trifluoromethylpyrazole (211256-76-7)

Guidance literature:

With tert.-butyl lithium; In tetrahydrofuran; for 3h; Heating;

DOI:10.1080/00397919808007030

Reference yield:

2-methyl-5-trifluoromethyl-2H-pyrazol-3-ol (122431-37-2) → 4-(4-methoxybenzoyl)-1-methyl-5-hydroxy-3-trifluoromethylpyrazole (211256-76-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / NBS / CHCl₃ / 1 h / -5 °C

2: 91 percent / Et₃N / CHCl₃ / 1 h / 0 - 20 °C

3: 81 percent / t-butyllithium / tetrahydrofuran / 3 h / Heating

With N-Bromosuccinimide; tert.-butyl lithium; triethylamine; In tetrahydrofuran; chloroform; 1: Bromination / 2: Esterification / 3: Rearrangement;

DOI:10.1080/00397919808007030

Reference yield:

4-bromo-1-methyl-5-hydroxypyrazole (122431-43-0) → 4-(4-methoxybenzoyl)-1-methyl-5-hydroxy-3-trifluoromethylpyrazole (211256-76-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / Et₃N / CHCl₃ / 1 h / 0 - 20 °C

2: 81 percent / t-butyllithium / tetrahydrofuran / 3 h / Heating

With tert.-butyl lithium; triethylamine; In tetrahydrofuran; chloroform; 1: Esterification / 2: Rearrangement;

DOI:10.1080/00397919808007030

upstream raw materials:

4-bromo-5-(4-methoxybenzoyl)oxy-1-methyl-3-trifluoromethylpyrazole

2-methyl-5-trifluoromethyl-2H-pyrazol-3-ol

4-bromo-1-methyl-5-hydroxypyrazole