methyl α-(p-nitrophenyl)-α-isocyanoacetate

Base Information

• Chemical Name: methyl α-(p-nitrophenyl)-α-isocyanoacetate
• CAS No.: 939047-03-7
• Molecular Formula: C₁₀H₈N₂O₄
• Molecular Weight: 220.185
• Mol file: 939047-03-7.mol

Synonyms:methyl α-(p-nitrophenyl)-α-isocyanoacetate

Chemical Property of methyl α-(p-nitrophenyl)-α-isocyanoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl α-(p-nitrophenyl)-α-isocyanoacetate

There total 4 articles about methyl α-(p-nitrophenyl)-α-isocyanoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

isocyanoacetic acid methyl ester (39687-95-1) + 4-Fluoronitrobenzene (350-46-9,178603-76-4) → methyl α-(p-nitrophenyl)-α-isocyanoacetate (939047-03-7)

Guidance literature:

isocyanoacetic acid methyl ester; With caesium carbonate; In dimethyl sulfoxide; at 20 ℃; for 0.166667h; Inert atmosphere;

4-Fluoronitrobenzene; In dimethyl sulfoxide; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/chem.201002098

Reference yield:

C10H10N2O5 → methyl α-(p-nitrophenyl)-α-isocyanoacetate (939047-03-7)

Guidance literature:

With diisopropylamine; trichlorophosphate; In dichloromethane; at -30 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/ja506031h

Reference yield:

C9H10N2O4*ClH → methyl α-(p-nitrophenyl)-α-isocyanoacetate (939047-03-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / 16 h / 50 °C / Inert atmosphere

2: diisopropylamine; trichlorophosphate / dichloromethane / 1.5 h / -30 °C / Inert atmosphere

With triethylamine; diisopropylamine; trichlorophosphate; In dichloromethane;

DOI:10.1021/ja506031h

upstream raw materials:

isocyanoacetic acid methyl ester

4-Fluoronitrobenzene

2-amino-2-(4-nitrophenyl)acetic acid

Downstream raw materials:

N-butyl-1-(5-methoxy-4-(4-nitrophenyl)oxazol-2-yl)heptan-1-amine