9-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-<(4-chlorophenyl)sulfanyl>-9H-purine

Base Information

Chemical Name:9-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-<(4-chlorophenyl)sulfanyl>-9H-purine
CAS No.:225111-66-0
Molecular Formula:C₂₀H₂₂ClN₅O₄S
Molecular Weight:463.945
Hs Code.:

Synonyms:9-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-<(4-chlorophenyl)sulfanyl>-9H-purine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-<(4-chlorophenyl)sulfanyl>-9H-purine

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 9-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-<(4-chlorophenyl)sulfanyl>-9H-purine

There total 11 articles about 9-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-<(4-chlorophenyl)sulfanyl>-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 108-24-7
acetic anhydride

: 225111-70-6
2-amino-6-<(4-chlorophenyl)sulfanyl>-9-<4-hydroxy-3-(hydroxymethyl)butyl>-9H-purine

: 225111-66-0
9-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-<(4-chlorophenyl)sulfanyl>-9H-purine

Guidance literature:: With pyridine; for 16h; Ambient temperature;
DOI:10.1016/S0040-4020(99)00169-6

Reference yield:

: 128139-38-8
Acetic acid 2-acetoxymethyl-4-methanesulfonyloxy-butyl ester

: 158665-15-7
2-amino-6-<(4-chlorophenyl)sulfanyl>purine

: 7-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-<(4-chlorophenyl)sulfanyl>-9H-purine

: 225111-66-0
9-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-<(4-chlorophenyl)sulfanyl>-9H-purine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 18h; Yield given; Yields of byproduct given;
DOI:10.1016/S0040-4020(99)00169-6

Reference yield:

: 73-40-5
2-amino-1,9-dihydro-6H-purin-6-one

: 225111-66-0
9-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-<(4-chlorophenyl)sulfanyl>-9H-purine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) trifluoroacetic anhydride / 1) pyridine, 0 deg C, 20 min; 2) pyridine, rt, 2 h

2: potassium carbonate / dimethylformamide / 18 h / 40 °C

With potassium carbonate; trifluoroacetic anhydride; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(99)00169-6