methyl 7-{ [3-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)benzoyl]amino}-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Base Information

Chemical Name:methyl 7-{ [3-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)benzoyl]amino}-1,2,3,4-tetrahydronaphthalene-2-carboxylate
CAS No.:1355371-31-1
Molecular Formula:C₂₄H₂₂F₃N₃O₃
Molecular Weight:457.452
Hs Code.:

Synonyms:methyl 7-{ [3-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)benzoyl]amino}-1,2,3,4-tetrahydronaphthalene-2-carboxylate

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Chemical Property of methyl 7-{ [3-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)benzoyl]amino}-1,2,3,4-tetrahydronaphthalene-2-carboxylate

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Technology Process of methyl 7-{ [3-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)benzoyl]amino}-1,2,3,4-tetrahydronaphthalene-2-carboxylate

There total 7 articles about methyl 7-{ [3-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)benzoyl]amino}-1,2,3,4-tetrahydronaphthalene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1237536-11-6
3-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)benzoic acid

: 1355371-24-2
methyl 7-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylate hydrochloride

: 1355371-31-1
methyl 7-{ [3-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)benzoyl]amino}-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Guidance literature:: 3-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)benzoic acid; With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃; for 0.25h;

methyl 7-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylate hydrochloride; at 20 ℃;

Reference yield:

: 187331-46-0
3-bromo-5-trifluoromethylbenzoic acid methyl ester

: 1355371-31-1
methyl 7-{ [3-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)benzoyl]amino}-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 80 °C

2.1: sodium hydroxide; methanol / 2 h / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 0.25 h / 20 °C

3.2: 20 °C

With pyridine; methanol; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane;

Reference yield:

: 31846-36-3
7-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

: 1355371-31-1
methyl 7-{ [3-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)benzoyl]amino}-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / Reflux

2.1: triethylamine / dichloromethane / 3 h / 20 °C / Cooling with ice

3.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 0.25 h / 20 °C

5.2: 20 °C

With pyridine; hydrogenchloride; sulfuric acid; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane;