2-amino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

Base Information

Chemical Name:2-amino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester
CAS No.:428874-40-2
Molecular Formula:C₁₉H₃₁NO₅Si
Molecular Weight:381.544
Hs Code.:

2-amino-3-(3-<i>tert</i>-butoxycarbonyloxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

Synonyms:2-amino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of 2-amino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

Chemical Property:

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Technology Process of 2-amino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

There total 5 articles about 2-amino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 428874-20-8
2-benzyloxycarbonylamino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

: 428874-40-2
2-amino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; under 2585.81 Torr;
DOI:10.1021/ja020091v

Reference yield:

: carbonic acid 3-bromomethyl-phenyl ester tert-butyl ester

: 428874-40-2
2-amino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / sodium hexamethyldisilazide / tetrahydrofuran; hexamethylphosphoric acid triamide / 3 h

2: H₂ / palladium dichloride / tetrahydrofuran; ethanol / 18 h / 2585.81 Torr

3: 1.92 g / NaHCO₃; NaOH / dioxane; H₂O / 0.67 h / 0 - 20 °C

4: 52 percent / EDC; diisipropylethylamine; DMAP / CH₂Cl₂ / 24 h

5: H₂ / Pd/C / ethanol / 2585.81 Torr

With dmap; sodium hydroxide; hydrogen; sodium hexamethyldisilazane; sodium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; palladium dichloride; In tetrahydrofuran; 1,4-dioxane; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; water;
DOI:10.1021/ja020091v

Reference yield:

: 2-amino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid

: 428874-40-2
2-amino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.92 g / NaHCO₃; NaOH / dioxane; H₂O / 0.67 h / 0 - 20 °C

2: 52 percent / EDC; diisipropylethylamine; DMAP / CH₂Cl₂ / 24 h

3: H₂ / Pd/C / ethanol / 2585.81 Torr

With dmap; sodium hydroxide; hydrogen; sodium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; water;
DOI:10.1021/ja020091v