6-chloro-7,8-dimethoxy-3-methyl-1-(3-chlorophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

Chemical Name:6-chloro-7,8-dimethoxy-3-methyl-1-(3-chlorophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS No.:67287-88-1
Molecular Formula:C₁₉H₂₁Cl₂NO₂
Molecular Weight:366.287
Hs Code.:

Synonyms:6-chloro-7,8-dimethoxy-3-methyl-1-(3-chlorophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

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Chemical Property of 6-chloro-7,8-dimethoxy-3-methyl-1-(3-chlorophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

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Technology Process of 6-chloro-7,8-dimethoxy-3-methyl-1-(3-chlorophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 4 articles about 6-chloro-7,8-dimethoxy-3-methyl-1-(3-chlorophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20697-04-5
3-chlorostyrene oxide

: 67287-88-1
6-chloro-7,8-dimethoxy-3-methyl-1-(3-chlorophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 18 h / 110 °C

2: 7.5 g / H₂SO₄, CF₃COOH / 2 h / Heating

3: 71 percent / aq. HCOOH / 4.5 h / Heating

With formic acid; sulfuric acid; trifluoroacetic acid;
DOI:10.1021/jm00346a005

Reference yield:

: 67287-36-9
2-(2-chloro-3,4-dimethoxyphenyl)ethylamine

: 67287-88-1
6-chloro-7,8-dimethoxy-3-methyl-1-(3-chlorophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 18 h / 110 °C

2: 7.5 g / H₂SO₄, CF₃COOH / 2 h / Heating

3: 71 percent / aq. HCOOH / 4.5 h / Heating

With formic acid; sulfuric acid; trifluoroacetic acid;
DOI:10.1021/jm00346a005

Reference yield:

: 587-04-2
m-Chlorobenzaldehyde

: 67287-88-1
6-chloro-7,8-dimethoxy-3-methyl-1-(3-chlorophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 50percent NaH suspension in mineral oil, Me₂SO / 1.) THF, 0 deg C, 5 min, 2.) a) 0 deg C, 15 min, b) 25 deg C, 2h

2: 18 h / 110 °C

3: 7.5 g / H₂SO₄, CF₃COOH / 2 h / Heating

4: 71 percent / aq. HCOOH / 4.5 h / Heating

With formic acid; sulfuric acid; sodium hydride; dimethyl sulfoxide; trifluoroacetic acid;
DOI:10.1021/jm00346a005