2-(4-methoxycarbonylphenyl)-5-formylbenzofuran

Base Information

• Chemical Name: 2-(4-methoxycarbonylphenyl)-5-formylbenzofuran
• CAS No.: 222308-72-7
• Molecular Formula: C₁₇H₁₂O₄
• Molecular Weight: 280.28

Synonyms:2-(4-methoxycarbonylphenyl)-5-formylbenzofuran

Chemical Property of 2-(4-methoxycarbonylphenyl)-5-formylbenzofuran

Chemical Property:

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Technology Process of 2-(4-methoxycarbonylphenyl)-5-formylbenzofuran

There total 1 articles about 2-(4-methoxycarbonylphenyl)-5-formylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

4-methoxycarbonyl-1-<1-(4-formylphenyloxyimino)ethyl>benzene → 2-(4-methoxycarbonylphenyl)-5-formylbenzofuran (222308-72-7)

Guidance literature:

With hydrogenchloride; acetic acid; at 100 ℃; for 12h;

DOI:10.1248/cpb.47.226

Reference yield: 90.0%

2-(4-methoxycarbonylphenyl)-5-formylbenzofuran (222308-72-7) → 2-(4-methoxycarbonylphenyl)benzofuran-5-carboxylic acid (222308-79-4)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In N,N-dimethyl acetamide; water; for 2h; Ambient temperature;

DOI:10.1248/cpb.47.226

Reference yield:

2-(4-methoxycarbonylphenyl)-5-formylbenzofuran (222308-72-7) → 4-<5-(N-diphenylmethylcarbamoyl)benzofuran-2-yl>benzoic acid

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / NaClO₂, NaH₂PO₄, 2-methyl-2-butene / N,N-dimethyl-acetamide; H₂O / 2 h / Ambient temperature

2: 2,4,6-triisopropylbenzenesulfonyl chloride, Et₃N, 4-dimethylaminopyridine / CH₂Cl₂ / 3 h / Ambient temperature

3: 15 percent aq. KOH / dioxane / 2 h / Heating

With dmap; potassium hydroxide; sodium chlorite; sodium dihydrogenphosphate; 2,4,6-triisopropylphenylsulfonyl chloride; 2-methyl-but-2-ene; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water;

DOI:10.1248/cpb.47.226

Downstream raw materials:

2-(4-methoxycarbonylphenyl)benzofuran-5-carboxylic acid

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