(S)-2-[((2S,3R,6S,8aS)-6-{2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-5-oxo-2-phenyl-hexahydro-thiazolo[3,2-a]pyridine-3-carbonyl)-amino]-4-methyl-pentanoic acid methyl ester

Base Information

Chemical Name:(S)-2-[((2S,3R,6S,8aS)-6-{2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-5-oxo-2-phenyl-hexahydro-thiazolo[3,2-a]pyridine-3-carbonyl)-amino]-4-methyl-pentanoic acid methyl ester
CAS No.:618457-57-1
Molecular Formula:C₃₇H₄₉N₅O₉S
Molecular Weight:739.89
Hs Code.:

(S)-2-[((2S,3R,6S,8aS)-6-{2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-5-oxo-2-phenyl-hexahydro-thiazolo[3,2-a]pyridine-3-carbonyl)-amino]-4-methyl-pentanoic acid methyl ester

Synonyms:(S)-2-[((2S,3R,6S,8aS)-6-{2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-5-oxo-2-phenyl-hexahydro-thiazolo[3,2-a]pyridine-3-carbonyl)-amino]-4-methyl-pentanoic acid methyl ester

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Chemical Property of (S)-2-[((2S,3R,6S,8aS)-6-{2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-5-oxo-2-phenyl-hexahydro-thiazolo[3,2-a]pyridine-3-carbonyl)-amino]-4-methyl-pentanoic acid methyl ester

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Technology Process of (S)-2-[((2S,3R,6S,8aS)-6-{2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-5-oxo-2-phenyl-hexahydro-thiazolo[3,2-a]pyridine-3-carbonyl)-amino]-4-methyl-pentanoic acid methyl ester

There total 10 articles about (S)-2-[((2S,3R,6S,8aS)-6-{2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-5-oxo-2-phenyl-hexahydro-thiazolo[3,2-a]pyridine-3-carbonyl)-amino]-4-methyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 618457-57-1
(S)-2-[((2S,3R,6S,8aS)-6-{2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-5-oxo-2-phenyl-hexahydro-thiazolo[3,2-a]pyridine-3-carbonyl)-amino]-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: BOP; HOBt; DIPEA / dimethylformamide

2: aq. NH₂NH₂ / ethanol; CHCl₃

3: HOBt; BOP; DIPEA / dimethylformamide

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1039/b302235h

Reference yield:

: (2R,3S)-2-Amino-3-mercapto-3-phenyl-propionic acid ethyl ester

: 618457-57-1
(S)-2-[((2S,3R,6S,8aS)-6-{2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-5-oxo-2-phenyl-hexahydro-thiazolo[3,2-a]pyridine-3-carbonyl)-amino]-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: HOAc / aq. ethanol

2: PhCH₂N(CH₃)3F

3: DCC; HOBt

4: BBr₃ / CH₂Cl₂

5: BOP; HOBt; DIPEA / dimethylformamide

6: aq. NH₂NH₂ / ethanol; CHCl₃

7: HOBt; BOP; DIPEA / dimethylformamide

With boron tribromide; trimethyl(benzyl)ammonium fluoride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1039/b302235h

Reference yield:

: (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-5-oxo-pentanoic acid 2-trimethylsilanyl-ethyl ester

: 618457-57-1
(S)-2-[((2S,3R,6S,8aS)-6-{2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-5-oxo-2-phenyl-hexahydro-thiazolo[3,2-a]pyridine-3-carbonyl)-amino]-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: HOAc / aq. ethanol

2: PhCH₂N(CH₃)3F

3: DCC; HOBt

4: BBr₃ / CH₂Cl₂

5: BOP; HOBt; DIPEA / dimethylformamide

6: aq. NH₂NH₂ / ethanol; CHCl₃

7: HOBt; BOP; DIPEA / dimethylformamide

With boron tribromide; trimethyl(benzyl)ammonium fluoride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1039/b302235h