1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]-3,3-bis(4-fluorophenyl)piperidin-2-one

Base Information

Chemical Name:1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]-3,3-bis(4-fluorophenyl)piperidin-2-one
CAS No.:1219624-92-6
Molecular Formula:C₃₆H₃₅F₂N₃O₂
Molecular Weight:579.69
Hs Code.:

Synonyms:1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]-3,3-bis(4-fluorophenyl)piperidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]-3,3-bis(4-fluorophenyl)piperidin-2-one

Chemical Property:

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Technology Process of 1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]-3,3-bis(4-fluorophenyl)piperidin-2-one

There total 5 articles about 1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]-3,3-bis(4-fluorophenyl)piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1219624-96-0
2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetic acid

: 841-77-0
diphenylmethylpiperazine

: 1219624-92-6
1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]-3,3-bis(4-fluorophenyl)piperidin-2-one

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: C₁₈H₁₅F₂NO₂

: 1219624-92-6
1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]-3,3-bis(4-fluorophenyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: methanol; ammonia / Heating

2: potassium tert-butylate

3: water; lithium hydroxide / ethanol

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

With methanol; dmap; potassium tert-butylate; ammonia; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In ethanol;
DOI:10.1016/j.bmcl.2011.12.100

Reference yield:

: 1219624-94-8
3,3-bis(4-fluorophenyl)piperidin-2-one

: 1219624-92-6
1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]-3,3-bis(4-fluorophenyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate

2: water; lithium hydroxide / ethanol

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

With dmap; potassium tert-butylate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In ethanol;
DOI:10.1016/j.bmcl.2011.12.100