(1S,2R,3S,6R)-2-Hydroxy-3-methyl-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester

Base Information

• Chemical Name: (1S,2R,3S,6R)-2-Hydroxy-3-methyl-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester
• CAS No.: 688800-86-4
• Molecular Formula: C₂₇H₂₆O₄
• Molecular Weight: 414.501
• Mol file: 688800-86-4.mol

Synonyms:(1S,2R,3S,6R)-2-Hydroxy-3-methyl-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester

Chemical Property of (1S,2R,3S,6R)-2-Hydroxy-3-methyl-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (1S,2R,3S,6R)-2-Hydroxy-3-methyl-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester

There total 2 articles about (1S,2R,3S,6R)-2-Hydroxy-3-methyl-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1E)-1-phenylpent-1-en-3-one (3152-68-9) + benzyl benzoylacetate (63888-22-2) → 2-hydroxy-3-methyl-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester + (1S,2R,3S,6R)-2-Hydroxy-3-methyl-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester (688800-86-4)

Guidance literature:

With 4-(S)-benzyl-1-methylimidazolidine-2-carboxylic acid; In ethanol; at 20 ℃; for 165h;

DOI:10.1002/anie.200353364

Reference yield:

(1E)-1-phenylpent-1-en-3-one (3152-68-9) + benzyl benzoylacetate (63888-22-2) → 2-hydroxy-3-methyl-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester + (1R,2S,3R,6S)-2-Hydroxy-3-methyl-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester + (1S,2R,3S,6R)-2-Hydroxy-3-methyl-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester (688800-86-4)

Guidance literature:

With 4-(S)-benzyl-1-methylimidazolidine-2-carboxylic acid; In ethanol; at 20 ℃; for 95h;

DOI:10.1002/anie.200353364

Reference yield: 85.0%

(1S,2R,3S,6R)-2-Hydroxy-3-methyl-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester (688800-86-4) → (1S,2R,3R,4R,6R)-2,4-Dihydroxy-3-methyl-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester

Guidance literature:

(1S,2R,3S,6R)-2-Hydroxy-3-methyl-4-oxo-2,6-diphenyl-cyclohexanecarboxylic acid benzyl ester; With L-Selectride; In tetrahydrofuran; at -70 - -10 ℃;

With sodium perborate; In water; at 60 ℃; for 4h;

DOI:10.1002/anie.200353364

upstream raw materials:

(1E)-1-phenylpent-1-en-3-one

benzyl benzoylacetate

Refernces