N-[4-(3-Methoxycarbonyl-propionylamino)-2-(quinolin-2-ylmethoxy)-phenyl]-succinamic acid methyl ester

Base Information

Chemical Name:N-[4-(3-Methoxycarbonyl-propionylamino)-2-(quinolin-2-ylmethoxy)-phenyl]-succinamic acid methyl ester
CAS No.:102650-02-2
Molecular Formula:C₂₆H₂₇N₃O₇
Molecular Weight:493.516
Hs Code.:

Synonyms:N-[4-(3-Methoxycarbonyl-propionylamino)-2-(quinolin-2-ylmethoxy)-phenyl]-succinamic acid methyl ester

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Chemical Property of N-[4-(3-Methoxycarbonyl-propionylamino)-2-(quinolin-2-ylmethoxy)-phenyl]-succinamic acid methyl ester

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Technology Process of N-[4-(3-Methoxycarbonyl-propionylamino)-2-(quinolin-2-ylmethoxy)-phenyl]-succinamic acid methyl ester

There total 4 articles about N-[4-(3-Methoxycarbonyl-propionylamino)-2-(quinolin-2-ylmethoxy)-phenyl]-succinamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 2-(Quinolin-2-ylmethoxy)-benzene-1,4-diamine

: 1490-25-1
succinic acid monomethylester chloride

: 102650-02-2
N-[4-(3-Methoxycarbonyl-propionylamino)-2-(quinolin-2-ylmethoxy)-phenyl]-succinamic acid methyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1021/jm00158a019

Reference yield:

: 4377-41-7
2-Chloromethylquinoline

: 102650-02-2
N-[4-(3-Methoxycarbonyl-propionylamino)-2-(quinolin-2-ylmethoxy)-phenyl]-succinamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: cesium carbonate, sodium carbonate, potassium iodide / acetone / 72 h / Heating

2: hydrochloric acid, iron / ethanol / Ambient temperature

3: 77 percent / triethylamine / tetrahydrofuran / 1 h / Ambient temperature

With hydrogenchloride; iron; sodium carbonate; caesium carbonate; triethylamine; potassium iodide; In tetrahydrofuran; ethanol; acetone;
DOI:10.1021/jm00158a019

Reference yield:

: 119481-61-7
4-Nitro-2-(quinolin-2-ylmethoxy)-phenylamine

: 102650-02-2
N-[4-(3-Methoxycarbonyl-propionylamino)-2-(quinolin-2-ylmethoxy)-phenyl]-succinamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrochloric acid, iron / ethanol / Ambient temperature

2: 77 percent / triethylamine / tetrahydrofuran / 1 h / Ambient temperature

With hydrogenchloride; iron; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00158a019