N-benzyloxycarbonylserylleucinamide

Base Information

• Chemical Name: N-benzyloxycarbonylserylleucinamide
• CAS No.: 17331-87-2
• Molecular Formula: C17H25 N3 O5
• Molecular Weight: 351.403
• Mol file: 17331-87-2.mol

Synonyms:Carbamicacid, [1-[(1-carbamoyl-3-methylbutyl)carbamoyl]-2-hydroxyethyl]-, benzyl ester(7CI,8CI); Leucinamide, N-carboxy-L-seryl-, benzyl ester, L- (8CI);Benzyloxycarbonyl-L-seryl-L-leucinamide

Chemical Property of N-benzyloxycarbonylserylleucinamide

Chemical Property:

• Vapor Pressure: 3.77E-18mmHg at 25°C
• Boiling Point: 656.9°Cat760mmHg
• Flash Point: 351.1°C
• PSA: 130.75000
• Density: 1.218g/cm³
• LogP: 1.77200

Purity/Quality:

99% ^*data from raw suppliers

CARBOBENZYLOXYSERYLLEUCINAMIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-benzyloxycarbonylserylleucinamide

There total 15 articles about N-benzyloxycarbonylserylleucinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

H-L-Leu-NH2 (687-51-4,13079-20-4,13366-40-0,15893-47-7) + N-benzyloxycarbonyl-L-serine methyl ester (1676-81-9) → Z-L-Ser-L-Leu-NH2 (17331-87-2)

Guidance literature:

With subtilisin-CLEC; In acetonitrile; at 40 ℃; for 28h;

DOI:10.1021/jo9618334

Reference yield: 92.4%

(2S)-amino-4-methylpentanamide hydrochloride (10466-61-2) + N-(benzyloxycarbonyl)-L-serine p-nitrobenzyl ester (6169-33-1) → Z-L-Ser-L-Leu-NH2 (17331-87-2)

Guidance literature:

With α-chymotrypsin immobilised on Celite; Tris buffer; triethylamine; In acetonitrile; at 30 ℃; for 48h; pH=7.8;

DOI:10.1039/b004180g

Reference yield: 91.3%

(2S)-amino-4-methylpentanamide hydrochloride (10466-61-2) + Z-L-Ser carbamoylmethyl ester (194658-69-0) → Z-L-Ser-L-Leu-NH2 (17331-87-2)

Guidance literature:

With α-chymotrypsin immobilised on Celite; Tris buffer; triethylamine; In acetonitrile; at 30 ℃; for 48h; pH=7.8;

DOI:10.1039/b004180g

upstream raw materials:

Z-Ser-Leu-OMe

N-(N-benzyloxycarbonyl-L-seryl)-L-leucine benzyl ester

H-L-Leu-NH₂

Z-Ser-N3