(2S)-N-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]propanamide

Base Information

Chemical Name:(2S)-N-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]propanamide
CAS No.:1616384-56-5
Molecular Formula:C₂₁H₂₁ClF₃N₅O
Molecular Weight:451.879
Hs Code.:

Synonyms:(2S)-N-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]propanamide

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Chemical Property of (2S)-N-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]propanamide

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Technology Process of (2S)-N-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]propanamide

There total 11 articles about (2S)-N-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1571823-07-8
(2S)-2-[2-methyl-4-(trifluoromethyl)imidazole-1-yl]propanoic acid

: 1613396-61-4
1-(4-chlorophenyl)-5-cylocbutyl-pyrazol-4-amine

: 1616384-56-5
(2S)-N-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]propanamide

Guidance literature:: With pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; acetonitrile; at 0 ℃; for 0.25h;

Reference yield:

: 137638-05-2
methyl 3-cyclobutyl-3-oxo-propanoate

: 1616384-56-5
(2S)-N-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1 h / 100 °C

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

3: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 1 h / 80 °C

4: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

5: pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; acetonitrile / 0.25 h / 0 °C

With pyridine; oxalyl dichloride; lithium hydroxide monohydrate; water; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1616384-75-8
C₁₆H₁₈F₃N₃O₂

: 1616384-56-5
(2S)-N-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / water; 1,4-dioxane / 6 h / 80 °C

2: pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; acetonitrile / 0.25 h / 0 °C

With pyridine; sulfuric acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In 1,4-dioxane; water; ethyl acetate; acetonitrile;