Methyl 8,8-Dimethoxy-6-exo-(3-iodoindol-2-yl)-2-<2-(phenylsulfonyl)prop-2-enyl>-2-azabicyclo<2.2.2>octane-6-endo-carboxylate

Base Information

Chemical Name:Methyl 8,8-Dimethoxy-6-exo-(3-iodoindol-2-yl)-2-<2-(phenylsulfonyl)prop-2-enyl>-2-azabicyclo<2.2.2>octane-6-endo-carboxylate
CAS No.:133372-28-8
Molecular Formula:C₂₈H₃₁IN₂O₆S
Molecular Weight:650.534
Hs Code.:

Synonyms:Methyl 8,8-Dimethoxy-6-exo-(3-iodoindol-2-yl)-2-<2-(phenylsulfonyl)prop-2-enyl>-2-azabicyclo<2.2.2>octane-6-endo-carboxylate

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Chemical Property of Methyl 8,8-Dimethoxy-6-exo-(3-iodoindol-2-yl)-2-<2-(phenylsulfonyl)prop-2-enyl>-2-azabicyclo<2.2.2>octane-6-endo-carboxylate

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Technology Process of Methyl 8,8-Dimethoxy-6-exo-(3-iodoindol-2-yl)-2-<2-(phenylsulfonyl)prop-2-enyl>-2-azabicyclo<2.2.2>octane-6-endo-carboxylate

There total 3 articles about Methyl 8,8-Dimethoxy-6-exo-(3-iodoindol-2-yl)-2-<2-(phenylsulfonyl)prop-2-enyl>-2-azabicyclo<2.2.2>octane-6-endo-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 133372-27-7
Methyl 8,8-Dimethoxy-6-exo-indol-2-yl-2-<2-(phenylsulfonyl)-2-propenyl>-2-azabicyclo<2.2.2>octane-6-endo-carboxylate

: 133372-28-8
Methyl 8,8-Dimethoxy-6-exo-(3-iodoindol-2-yl)-2-<2-(phenylsulfonyl)prop-2-enyl>-2-azabicyclo<2.2.2>octane-6-endo-carboxylate

Guidance literature:: With N-iodo-succinimide; In acetone; for 0.25h; Ambient temperature;
DOI:10.1021/jo00311a022

Reference yield:

: 110426-92-1
[(3-bromoprop-1-en-2-yl)sulfonyl]benzene

: 133372-28-8
Methyl 8,8-Dimethoxy-6-exo-(3-iodoindol-2-yl)-2-<2-(phenylsulfonyl)prop-2-enyl>-2-azabicyclo<2.2.2>octane-6-endo-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / Na₂CO₃ / acetonitrile / 4 h / Ambient temperature

2: 85 percent / N-iodosuccinimide / acetone / 0.25 h / Ambient temperature

With N-iodo-succinimide; sodium carbonate; In acetone; acetonitrile;
DOI:10.1021/jo00311a022

Reference yield:

: 133372-16-4
Methyl 8,8-Dimethoxy-6-exo-(indol-2-yl)-2-azabicyclo<2.2.2>octane-6-endo-carboxylate

: 133372-28-8
Methyl 8,8-Dimethoxy-6-exo-(3-iodoindol-2-yl)-2-<2-(phenylsulfonyl)prop-2-enyl>-2-azabicyclo<2.2.2>octane-6-endo-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / Na₂CO₃ / acetonitrile / 4 h / Ambient temperature

2: 85 percent / N-iodosuccinimide / acetone / 0.25 h / Ambient temperature

With N-iodo-succinimide; sodium carbonate; In acetone; acetonitrile;
DOI:10.1021/jo00311a022