(2R,3S)-4-[(2S,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-diphenyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-butyraldehyde

Base Information

Chemical Name:(2R,3S)-4-[(2S,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-diphenyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-butyraldehyde
CAS No.:262614-92-6
Molecular Formula:C₄₅H₆₆O₇Si₂
Molecular Weight:775.186
Hs Code.:

(2R,3S)-4-[(2S,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-diphenyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-butyraldehyde

Synonyms:(2R,3S)-4-[(2S,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-diphenyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-butyraldehyde

Suppliers and Price of (2R,3S)-4-[(2S,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-diphenyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-butyraldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S)-4-[(2S,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-diphenyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-butyraldehyde

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S)-4-[(2S,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-diphenyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-butyraldehyde

There total 5 articles about (2R,3S)-4-[(2S,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-diphenyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-butyraldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ((2R,4S,6R,8R,10S)-8-Allyl-2-benzyloxymethyl-10-methoxy-1,7-dioxa-spiro[5.5]undec-4-yloxy)-tert-butyl-diphenyl-silane

: 262614-92-6
(2R,3S)-4-[(2S,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-diphenyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-butyraldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: OsO₄; NMO / H₂O; tetrahydrofuran / 0.83 h / 20 °C

2: NaIO₄ / H₂O; tetrahydrofuran / 1.5 h / 20 °C

3: 96 percent / Sn(OTf)2; N-ethylpiperidine / CH₂Cl₂ / 3.25 h / -78 °C

4: 95 percent / Me₃Al / hexane; CH₂Cl₂; tetrahydrofuran / 1.83 h / -5 °C

5: 88 percent / 2,6-lutidine / CH₂Cl₂ / 1.25 h / -20 °C

6: 100 percent / Dibal-H / tetrahydrofuran / 0.25 h / -78 °C

With 1-ethyl-piperidine; 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; tin(II) trifluoromethanesulfonate; N-methyl-2-indolinone; trimethylaluminum; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; water; 1: dihydroxylation / 2: Oxidation / 3: Addition / 4: Substitution / 5: Condensation / 6: Reduction;
DOI:10.1021/ol0000049

Reference yield:

: [(2S,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-diphenyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-acetaldehyde

: 262614-92-6
(2R,3S)-4-[(2S,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-diphenyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-butyraldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / Sn(OTf)2; N-ethylpiperidine / CH₂Cl₂ / 3.25 h / -78 °C

2: 95 percent / Me₃Al / hexane; CH₂Cl₂; tetrahydrofuran / 1.83 h / -5 °C

3: 88 percent / 2,6-lutidine / CH₂Cl₂ / 1.25 h / -20 °C

4: 100 percent / Dibal-H / tetrahydrofuran / 0.25 h / -78 °C

With 1-ethyl-piperidine; 2,6-dimethylpyridine; tin(II) trifluoromethanesulfonate; trimethylaluminum; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; 1: Addition / 2: Substitution / 3: Condensation / 4: Reduction;
DOI:10.1021/ol0000049

Reference yield:

: 3-[(2R,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-diphenyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-propane-1,2-diol

: 262614-92-6
(2R,3S)-4-[(2S,4S,6R,8R,10S)-8-Benzyloxymethyl-10-(tert-butyl-diphenyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-butyraldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: NaIO₄ / H₂O; tetrahydrofuran / 1.5 h / 20 °C

2: 96 percent / Sn(OTf)2; N-ethylpiperidine / CH₂Cl₂ / 3.25 h / -78 °C

3: 95 percent / Me₃Al / hexane; CH₂Cl₂; tetrahydrofuran / 1.83 h / -5 °C

4: 88 percent / 2,6-lutidine / CH₂Cl₂ / 1.25 h / -20 °C

5: 100 percent / Dibal-H / tetrahydrofuran / 0.25 h / -78 °C

With 1-ethyl-piperidine; 2,6-dimethylpyridine; sodium periodate; tin(II) trifluoromethanesulfonate; trimethylaluminum; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; water; 1: Oxidation / 2: Addition / 3: Substitution / 4: Condensation / 5: Reduction;
DOI:10.1021/ol0000049