(S)-ethyl-2-ethoxycarbonyl-3-(3-indolyl)-3-(p-trifluoromethylphenyl)propanoate

Base Information

Chemical Name:(S)-ethyl-2-ethoxycarbonyl-3-(3-indolyl)-3-(p-trifluoromethylphenyl)propanoate
CAS No.:1072095-80-7
Molecular Formula:C₂₃H₂₂F₃NO₄
Molecular Weight:433.427
Hs Code.:

Synonyms:(S)-ethyl-2-ethoxycarbonyl-3-(3-indolyl)-3-(p-trifluoromethylphenyl)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-ethyl-2-ethoxycarbonyl-3-(3-indolyl)-3-(p-trifluoromethylphenyl)propanoate

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Technology Process of (S)-ethyl-2-ethoxycarbonyl-3-(3-indolyl)-3-(p-trifluoromethylphenyl)propanoate

There total 2 articles about (S)-ethyl-2-ethoxycarbonyl-3-(3-indolyl)-3-(p-trifluoromethylphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 120-72-9
indole

: 905451-26-5
diethyl 2-[4-(trifluoromethyl)benzylidene]malonate

: 1072095-80-7
(S)-ethyl-2-ethoxycarbonyl-3-(3-indolyl)-3-(p-trifluoromethylphenyl)propanoate

Guidance literature:: diethyl 2-[4-(trifluoromethyl)benzylidene]malonate; With copper(II) bis(trifluoromethanesulfonate); (S,S)-(4-isopropyl-4,5-dihydrooxazol-2-yl)-(4-isopropyl-4,5-dihydrooxazol-2-yl)amine; In ethanol; for 0.333333h; under air;

indole; In ethanol; at 20 ℃; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/chem.200800508

Reference yield:

: 120-72-9
indole

: 905451-26-5
diethyl 2-[4-(trifluoromethyl)benzylidene]malonate

: 1072095-80-7
(S)-ethyl-2-ethoxycarbonyl-3-(3-indolyl)-3-(p-trifluoromethylphenyl)propanoate

: (R)-ethyl-2-ethoxycarbonyl-3-(3-indolyl)-3-(p-trifluoromethylphenyl)propanoate

Guidance literature:: diethyl 2-[4-(trifluoromethyl)benzylidene]malonate; With copper(II) bis(trifluoromethanesulfonate); (S,S)-(4-isopropyl-4,5-dihydrooxazol-2-yl)-(4-isopropyl-4,5-dihydrooxazol-2-yl)amine; In ethanol; for 0.333333h; under air;

indole; In ethanol; at 20 ℃; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/chem.200800508