7-(N^α-benzyloxycarbonyl-N^ε-t-butoxycarbonyl-L-lysyl)amino-4-methylcoumarin

Base Information

Chemical Name:7-(N^α-benzyloxycarbonyl-N^ε-t-butoxycarbonyl-L-lysyl)amino-4-methylcoumarin
CAS No.:236414-37-2
Molecular Formula:C₂₉H₃₅N₃O₇
Molecular Weight:537.613
Hs Code.:

7-(N<sup>α</sup>-benzyloxycarbonyl-N<sup>ε</sup>-t-butoxycarbonyl-L-lysyl)amino-4-methylcoumarin

Synonyms:7-(N^α-benzyloxycarbonyl-N^ε-t-butoxycarbonyl-L-lysyl)amino-4-methylcoumarin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-(N^α-benzyloxycarbonyl-N^ε-t-butoxycarbonyl-L-lysyl)amino-4-methylcoumarin

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Technology Process of 7-(N^α-benzyloxycarbonyl-N^ε-t-butoxycarbonyl-L-lysyl)amino-4-methylcoumarin

There total 5 articles about 7-(N^α-benzyloxycarbonyl-N^ε-t-butoxycarbonyl-L-lysyl)amino-4-methylcoumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 222037-62-9
tert-butyl (S)-(5-amino-6-((4-methyl-2-oxo-2H-chromen-7-yl)-amino)-6-oxohexyl) carbamate

: 236414-37-2
7-(N^α-benzyloxycarbonyl-N^ε-t-butoxycarbonyl-L-lysyl)amino-4-methylcoumarin

Guidance literature:: With sodium carbonate; In 1,4-dioxane; water; at 0 - 25 ℃; for 4h;
DOI:10.1039/c7ra05824a

Reference yield: 71.0%

: 26093-31-2
7-amino-4-methylcoumarin.

: 2389-60-8
Z-Lys(Boc)-OH

: 236414-37-2
7-(N^α-benzyloxycarbonyl-N^ε-t-butoxycarbonyl-L-lysyl)amino-4-methylcoumarin

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 8h;
DOI:10.1021/ml3002709

Reference yield:

: 26093-31-2
7-amino-4-methylcoumarin.

: 236414-37-2
7-(N^α-benzyloxycarbonyl-N^ε-t-butoxycarbonyl-L-lysyl)amino-4-methylcoumarin

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; trichlorophosphate / tetrahydrofuran / 3 h / 0 - 25 °C

2.1: piperidine / acetonitrile / 16 h / 4 °C

2.2: 8 h / 20 - 25 °C

3.1: sodium carbonate / water; 1,4-dioxane / 4 h / 0 - 25 °C

With piperidine; pyridine; sodium carbonate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile;
DOI:10.1039/c7ra05824a