1-mesityl-4,4-dimethyl-5-(2-nitro-1-phenylethyl)-1,2,3,4-tetrahydropyridine

Base Information

Chemical Name:1-mesityl-4,4-dimethyl-5-(2-nitro-1-phenylethyl)-1,2,3,4-tetrahydropyridine
CAS No.:1429754-90-4
Molecular Formula:C₂₄H₃₀N₂O₂
Molecular Weight:378.514
Hs Code.:

Synonyms:1-mesityl-4,4-dimethyl-5-(2-nitro-1-phenylethyl)-1,2,3,4-tetrahydropyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-mesityl-4,4-dimethyl-5-(2-nitro-1-phenylethyl)-1,2,3,4-tetrahydropyridine

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Technology Process of 1-mesityl-4,4-dimethyl-5-(2-nitro-1-phenylethyl)-1,2,3,4-tetrahydropyridine

There total 4 articles about 1-mesityl-4,4-dimethyl-5-(2-nitro-1-phenylethyl)-1,2,3,4-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 102-96-5
(2-nitroethenyl)benzene

: 1429754-62-0
1-mesityl-4,4-dimethylpiperidine

: 1429754-90-4
1-mesityl-4,4-dimethyl-5-(2-nitro-1-phenylethyl)-1,2,3,4-tetrahydropyridine

: 1429755-22-5
1-mesityl-4,4-dimethyl-1,2,3,4-tetrahydropyridine:

Guidance literature:: With dmap; iron(III) chloride; di-tert-butyl peroxide; In 1,2-dichloro-ethane; at 80 ℃; for 34h; Inert atmosphere;
DOI:10.1021/ol400568u

Reference yield:

: 53120-74-4
3,3-dimethylpent-1,5-diol

: 1429754-90-4
1-mesityl-4,4-dimethyl-5-(2-nitro-1-phenylethyl)-1,2,3,4-tetrahydropyridine

: 1429755-22-5
1-mesityl-4,4-dimethyl-1,2,3,4-tetrahydropyridine:

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1.08 h / -20 °C / Inert atmosphere

2: lithium bromide / acetone / 6 h / Reflux

3: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 40 h / 100 °C

4: iron(III) chloride; dmap; di-tert-butyl peroxide / 1,2-dichloro-ethane / 34 h / 80 °C / Inert atmosphere

With dmap; iron(III) chloride; di-tert-butyl peroxide; potassium carbonate; triethylamine; sodium iodide; lithium bromide; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol400568u

Reference yield:

: 96747-32-9
1,5-bis(mesyloxy)-3,3-dimethylpentane

: 1429754-90-4
1-mesityl-4,4-dimethyl-5-(2-nitro-1-phenylethyl)-1,2,3,4-tetrahydropyridine

: 1429755-22-5
1-mesityl-4,4-dimethyl-1,2,3,4-tetrahydropyridine:

Guidance literature:: Multi-step reaction with 3 steps

1: lithium bromide / acetone / 6 h / Reflux

2: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 40 h / 100 °C

3: iron(III) chloride; dmap; di-tert-butyl peroxide / 1,2-dichloro-ethane / 34 h / 80 °C / Inert atmosphere

With dmap; iron(III) chloride; di-tert-butyl peroxide; potassium carbonate; sodium iodide; lithium bromide; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol400568u