(5-chloro-2-(pyrimidin-2-yl)phenyl)((1S,3S,6R)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptan-2-yl)methanone

Base Information

Chemical Name:(5-chloro-2-(pyrimidin-2-yl)phenyl)((1S,3S,6R)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptan-2-yl)methanone
CAS No.:1456892-17-3
Molecular Formula:C₂₄H₂₁ClF₃N₅O
Molecular Weight:487.912
Hs Code.:

Synonyms:(5-chloro-2-(pyrimidin-2-yl)phenyl)((1S,3S,6R)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptan-2-yl)methanone

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Chemical Property of (5-chloro-2-(pyrimidin-2-yl)phenyl)((1S,3S,6R)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptan-2-yl)methanone

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Technology Process of (5-chloro-2-(pyrimidin-2-yl)phenyl)((1S,3S,6R)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptan-2-yl)methanone

There total 13 articles about (5-chloro-2-(pyrimidin-2-yl)phenyl)((1S,3S,6R)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptan-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1456892-94-6
C₂₀H₁₈ClF₃IN₃O

: 153435-63-3
2-(tributylstannyl)pyrimidine

: 1456892-17-3
(5-chloro-2-(pyrimidin-2-yl)phenyl)((1S,3S,6R)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptan-2-yl)methanone

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride; In N,N-dimethyl-formamide; at 130 ℃; for 0.166667h; Inert atmosphere; Microwave irradiation;

Reference yield:

: (3S)-tert-butyl 3-(hydroxymethyl)-2-azabicyclo[4.1.0]heptane-2-carboxylate

: 1456892-17-3
(5-chloro-2-(pyrimidin-2-yl)phenyl)((1S,3S,6R)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptan-2-yl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 3 h / 0 - 20 °C

2: hydrazine hydrate / ethanol / 16 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 120 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5: triethylamine / dichloromethane / 0.5 h / 20 °C

6: cesium fluoride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.17 h / 130 °C / Inert atmosphere; Microwave irradiation

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrazine hydrate; potassium carbonate; triethylamine; triphenylphosphine; cesium fluoride; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 13421-00-6
5-chloro-2-iodo-benzoic acid

: 1456892-17-3
(5-chloro-2-(pyrimidin-2-yl)phenyl)((1S,3S,6R)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptan-2-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / toluene / 3 h / 100 °C

2: triethylamine / dichloromethane / 0.5 h / 20 °C

3: cesium fluoride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.17 h / 130 °C / Inert atmosphere; Microwave irradiation

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; triethylamine; cesium fluoride; In dichloromethane; N,N-dimethyl-formamide; toluene;