(S)-ethyl 2-(tert-butoxy)-2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

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Chemical Name:(S)-ethyl 2-(tert-butoxy)-2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)acetate
CAS No.:1364599-78-9
Molecular Formula:C₂₂H₂₅Cl₂N₃O₃
Molecular Weight:450.365
Hs Code.:

Synonyms:(S)-ethyl 2-(tert-butoxy)-2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

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Chemical Property of (S)-ethyl 2-(tert-butoxy)-2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

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Technology Process of (S)-ethyl 2-(tert-butoxy)-2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

There total 4 articles about (S)-ethyl 2-(tert-butoxy)-2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.5%

: 540-88-5
acetic acid tert-butyl ester

: 1364599-76-7
(S)-ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxyacetate

: 1364599-78-9
(S)-ethyl 2-(tert-butoxy)-2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

Guidance literature:: With perchloric acid; In dichloromethane; for 2.5h;

Reference yield:

: 1115-30-6
diethyl acetylsuccinate

: 1364599-78-9
(S)-ethyl 2-(tert-butoxy)-2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / o-xylene / 2 h / 120 °C

2.1: trichlorophosphate; N,N-dimethyl-aniline / 3 h / 120 °C

3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.83 h / -78 °C

3.2: 2.5 h / -78 °C

4.1: Dess-Martin periodane / dichloromethane / 1 h

5.1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole / toluene; tetrahydrofuran / 18.02 h / -40 - 20 °C

5.2: 0.5 h

6.1: perchloric acid / dichloromethane / 2.5 h

With perchloric acid; potassium hexamethylsilazane; Dess-Martin periodane; N,N-dimethyl-aniline; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; trichlorophosphate; benzo[1,3,2]dioxaborole; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; o-xylene; toluene;

Reference yield:

: 1187767-15-2
3-(3-chlorophenyl)-4-methyl-1H-pyrazol-5-amine

: 1364599-78-9
(S)-ethyl 2-(tert-butoxy)-2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / o-xylene / 2 h / 120 °C

2.1: trichlorophosphate; N,N-dimethyl-aniline / 3 h / 120 °C

3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.83 h / -78 °C

3.2: 2.5 h / -78 °C

4.1: Dess-Martin periodane / dichloromethane / 1 h

5.1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole / toluene; tetrahydrofuran / 18.02 h / -40 - 20 °C

5.2: 0.5 h

6.1: perchloric acid / dichloromethane / 2.5 h

With perchloric acid; potassium hexamethylsilazane; Dess-Martin periodane; N,N-dimethyl-aniline; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; trichlorophosphate; benzo[1,3,2]dioxaborole; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; o-xylene; toluene;