C₂₀H₁₆ClF₂N₅O

Base Information

Chemical Name:C₂₀H₁₆ClF₂N₅O
CAS No.:1428557-62-3
Molecular Formula:C₂₀H₁₆ClF₂N₅O
Molecular Weight:415.83
Hs Code.:

C<sub>20</sub>H<sub>16</sub>ClF<sub>2</sub>N<sub>5</sub>O

Synonyms:C₂₀H₁₆ClF₂N₅O

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₀H₁₆ClF₂N₅O

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Technology Process of C₂₀H₁₆ClF₂N₅O

There total 6 articles about C₂₀H₁₆ClF₂N₅O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1428558-48-8
N-(3-chloro-4-(difluoromethoxy)phenyl)-5-(2-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)ethyl)pyrimidin-2-amine

: 1428557-62-3
C₂₀H₁₆ClF₂N₅O

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 478828-53-4
5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

: 1428557-62-3
C₂₀H₁₆ClF₂N₅O

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / water; toluene / 4 h / 110 °C

2: tetrabutyl-ammonium chloride; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 12 h / 120 °C

3: palladium on activated charcoal; hydrogen / ethyl acetate / 12 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

With palladium on activated charcoal; tetrabutyl-ammonium chloride; hydrogen; palladium diacetate; potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1428558-62-6
1-(tetrahydro-2H-pyran-2-yl)-5-vinyl-1H-indazole

: 1428557-62-3
C₂₀H₁₆ClF₂N₅O

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl-ammonium chloride; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 12 h / 120 °C

2: palladium on activated charcoal; hydrogen / ethyl acetate / 12 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

With palladium on activated charcoal; tetrabutyl-ammonium chloride; hydrogen; palladium diacetate; triethylamine; trifluoroacetic acid; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;