Technology Process of C14H18F3NO2
There total 3 articles about C14H18F3NO2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diphenyl phosphoryl azide;
In
tert-butyl alcohol;
at 110 ℃;
for 10h;
optical yield given as %ee;
Inert atmosphere;
Molecular sieve;
DOI:10.1021/ja9053338
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane; water; N,N-dimethyl-formamide / 2 h / -20 °C
2: diphenyl phosphoryl azide / tert-butyl alcohol / 10 h / 110 °C / Inert atmosphere; Molecular sieve
With
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; diphenyl phosphoryl azide;
In
dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
2: Curtius rearrangement;
DOI:10.1021/ja9053338
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 2,6-dimethylpyridine; Ir(ppy)2(dtb-bpy)PF6; (2R,5S)-2-tert-butyl 3,5-dimethylimidazolidin-4-one trifluoroacetic acid salt / N,N-dimethyl-formamide / 7.5 h / -20 °C / fluorescent light
2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane; water; N,N-dimethyl-formamide / 2 h / -20 °C
3: diphenyl phosphoryl azide / tert-butyl alcohol / 10 h / 110 °C / Inert atmosphere; Molecular sieve
With
2,6-dimethylpyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; Ir(ppy)2(dtb-bpy)PF6; (2R,5S)-2-tert-butyl 3,5-dimethylimidazolidin-4-one trifluoroacetic acid salt; diphenyl phosphoryl azide;
In
dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
3: Curtius rearrangement;
DOI:10.1021/ja9053338
