(1S,2S,3S,7R,7aS)-1,2-bis(benzyloxy)-3-((benzyloxy)methyl)-7-(4-methoxyphenyl)hexahydro-1H-pyrrolizine

Base Information

Chemical Name:(1S,2S,3S,7R,7aS)-1,2-bis(benzyloxy)-3-((benzyloxy)methyl)-7-(4-methoxyphenyl)hexahydro-1H-pyrrolizine
CAS No.:1446438-17-0
Molecular Formula:C₃₆H₃₉NO₄
Molecular Weight:549.71
Hs Code.:

Synonyms:(1S,2S,3S,7R,7aS)-1,2-bis(benzyloxy)-3-((benzyloxy)methyl)-7-(4-methoxyphenyl)hexahydro-1H-pyrrolizine

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Chemical Property of (1S,2S,3S,7R,7aS)-1,2-bis(benzyloxy)-3-((benzyloxy)methyl)-7-(4-methoxyphenyl)hexahydro-1H-pyrrolizine

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Technology Process of (1S,2S,3S,7R,7aS)-1,2-bis(benzyloxy)-3-((benzyloxy)methyl)-7-(4-methoxyphenyl)hexahydro-1H-pyrrolizine

There total 3 articles about (1S,2S,3S,7R,7aS)-1,2-bis(benzyloxy)-3-((benzyloxy)methyl)-7-(4-methoxyphenyl)hexahydro-1H-pyrrolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1446437-75-7
(1R,5S,6S,7S,7aS)-6,7-bis(benzyloxy)-5-((benzyloxy)methyl)-1-(4-methoxyphenyl)tetrahydro-1H-pyrrolizin-3(2H)-one

: 1446438-17-0
(1S,2S,3S,7R,7aS)-1,2-bis(benzyloxy)-3-((benzyloxy)methyl)-7-(4-methoxyphenyl)hexahydro-1H-pyrrolizine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h; Reflux;
DOI:10.1039/c3ob40696b

Reference yield:

: C₃₇H₄₁NO₆

: 1446438-17-0
(1S,2S,3S,7R,7aS)-1,2-bis(benzyloxy)-3-((benzyloxy)methyl)-7-(4-methoxyphenyl)hexahydro-1H-pyrrolizine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / deuteromethanol / 55 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Reflux

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; deuteromethanol;
DOI:10.1039/c3ob40696b

Reference yield:

: 1446437-55-3
(R)-methyl 3-((2S,3S,4S,5S)-3,4-bis(benzyloxy)-5-((benzyloxy)-methyl)-1-hydroxypyrrolidin-2-yl)-3-(4-methoxyphenyl)-propanoate

: 1446438-17-0
(1S,2S,3S,7R,7aS)-1,2-bis(benzyloxy)-3-((benzyloxy)methyl)-7-(4-methoxyphenyl)hexahydro-1H-pyrrolizine

Guidance literature:: Multi-step reaction with 3 steps

1: zinc; copper(II) acetate monohydrate; acetic acid / 20 - 50 °C

2: potassium carbonate / deuteromethanol / 55 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Reflux

With lithium aluminium tetrahydride; copper(II) acetate monohydrate; potassium carbonate; acetic acid; zinc; In tetrahydrofuran; deuteromethanol;
DOI:10.1039/c3ob40696b