3-(4-Chloro-phenyl)-1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine; hydrochloride

Base Information

Chemical Name:3-(4-Chloro-phenyl)-1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine; hydrochloride
CAS No.:95936-15-5
Molecular Formula:C₁₃H₁₄ClN₃*ClH
Molecular Weight:284.188
Hs Code.:

Synonyms:3-(4-Chloro-phenyl)-1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine; hydrochloride

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Chemical Property of 3-(4-Chloro-phenyl)-1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine; hydrochloride

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Technology Process of 3-(4-Chloro-phenyl)-1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine; hydrochloride

There total 5 articles about 3-(4-Chloro-phenyl)-1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 87628-75-9
1-[3-(4-Chloro-phenyl)-1-methyl-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-ethanone

: 95936-15-5
3-(4-Chloro-phenyl)-1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine; hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; for 2h; Heating;
DOI:10.1021/jm00145a015

Reference yield:

: 32161-06-1
1-acetyl-4-piperidinone

: 95936-15-5
3-(4-Chloro-phenyl)-1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: p-toluenesulfonic acid / benzene / 8 h / Heating

2: triethylamine / CH₂Cl₂ / 20 h / Ambient temperature

3: 98percent hydrazine hydrate / aq. ethanol / 3 h / Ambient temperature

4: 1.) NaH / 1.) DMF, 50 deg C, 30 min, 2.) DMF, 50 deg C, 2 h

5: 87 percent / 10percent aq.HCl / ethanol / 2 h / Heating

With hydrogenchloride; sodium hydride; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; benzene;
DOI:10.1021/jm00145a015

Reference yield:

: 55459-60-4
1-(4-(morpholin-4-yl)-3,6-dihydro-2H-pyridin-1-yl)ethanone

: 95936-15-5
3-(4-Chloro-phenyl)-1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / CH₂Cl₂ / 20 h / Ambient temperature

2: 98percent hydrazine hydrate / aq. ethanol / 3 h / Ambient temperature

3: 1.) NaH / 1.) DMF, 50 deg C, 30 min, 2.) DMF, 50 deg C, 2 h

4: 87 percent / 10percent aq.HCl / ethanol / 2 h / Heating

With hydrogenchloride; sodium hydride; hydrazine hydrate; triethylamine; In ethanol; dichloromethane;
DOI:10.1021/jm00145a015