(2S,3R,4S)-N-benzyloxycarbonyl-4-hydroxy-3-methoxymethyloxy-2-trityloxymethylpyrrolidine

Base Information

Chemical Name:(2S,3R,4S)-N-benzyloxycarbonyl-4-hydroxy-3-methoxymethyloxy-2-trityloxymethylpyrrolidine
CAS No.:176718-68-6
Molecular Formula:C₃₄H₃₅NO₆
Molecular Weight:553.655
Hs Code.:

Synonyms:(2S,3R,4S)-N-benzyloxycarbonyl-4-hydroxy-3-methoxymethyloxy-2-trityloxymethylpyrrolidine

Suppliers and Price of (2S,3R,4S)-N-benzyloxycarbonyl-4-hydroxy-3-methoxymethyloxy-2-trityloxymethylpyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R,4S)-N-benzyloxycarbonyl-4-hydroxy-3-methoxymethyloxy-2-trityloxymethylpyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R,4S)-N-benzyloxycarbonyl-4-hydroxy-3-methoxymethyloxy-2-trityloxymethylpyrrolidine

There total 8 articles about (2S,3R,4S)-N-benzyloxycarbonyl-4-hydroxy-3-methoxymethyloxy-2-trityloxymethylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 176718-67-5
(2S,3R,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-3-methoxymethoxy-2-trityloxymethyl-pyrrolidine-1-carboxylic acid benzyl ester

: 176718-68-6
(2S,3R,4S)-N-benzyloxycarbonyl-4-hydroxy-3-methoxymethyloxy-2-trityloxymethylpyrrolidine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h; Ambient temperature;
DOI:10.1248/cpb.44.587

Reference yield:

: 76-83-5
trityl chloride

: 176718-68-6
(2S,3R,4S)-N-benzyloxycarbonyl-4-hydroxy-3-methoxymethyloxy-2-trityloxymethylpyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N, 4-dimethylaminopyridine / CH₂Cl₂ / 8 h / Ambient temperature

2: imidazole, N,N-dimethylformamide / 2 h / 0 °C

3: 89 percent / N,N-diisopropylethylamine / tetrahydrofuran / 0.33 h / Heating

4: 82 percent / 1 M tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.44.587

Reference yield:

: 129492-78-0
(2S,3R,4S)-N-benzyloxycarbonyl-3,4-dihydroxy-2-hydroxymethylpyrrolidine

: 176718-68-6
(2S,3R,4S)-N-benzyloxycarbonyl-4-hydroxy-3-methoxymethyloxy-2-trityloxymethylpyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N, 4-dimethylaminopyridine / CH₂Cl₂ / 8 h / Ambient temperature

2: imidazole, N,N-dimethylformamide / 2 h / 0 °C

3: 89 percent / N,N-diisopropylethylamine / tetrahydrofuran / 0.33 h / Heating

4: 82 percent / 1 M tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.44.587