N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-2-methylpropanoyl-L-phenylalanine tert-butyl ester

Base Information

Chemical Name:N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-2-methylpropanoyl-L-phenylalanine tert-butyl ester
CAS No.:847165-24-6
Molecular Formula:C₄₇H₆₀N₆O₉
Molecular Weight:853.028
Hs Code.:

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-2-methylpropanoyl-L-phenylalanine tert-butyl ester

Synonyms:N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-2-methylpropanoyl-L-phenylalanine tert-butyl ester

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Chemical Property of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-2-methylpropanoyl-L-phenylalanine tert-butyl ester

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Technology Process of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-2-methylpropanoyl-L-phenylalanine tert-butyl ester

There total 7 articles about N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-2-methylpropanoyl-L-phenylalanine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 15100-75-1,75898-47-4
L-phenylalanine tert-butyl ester hydrochloride

: 847165-23-5
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-2-methylpropanoic acid

: 847165-24-6
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-2-methylpropanoyl-L-phenylalanine tert-butyl ester

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile; at 20 ℃;
DOI:10.1002/hlca.200490275

Reference yield:

: Z-Gly-Aib-Aib-N(Me)Ph

: 847165-24-6
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-2-methylpropanoyl-L-phenylalanine tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / H₂ / Pd/C / methanol

2: 69 percent / PyBOP; N-ethyl-diisopropylamine / CH₂Cl₂; acetonitrile / 20 °C

3: 91 percent / aq. HCl / H₂O; acetonitrile / 20 °C

4: 81 percent / PyBOP; N-ethyl-diisopropylamine / CH₂Cl₂; acetonitrile / 20 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; water; acetonitrile;
DOI:10.1002/hlca.200490275

Reference yield:

: 71989-31-6
Fmoc-Pro-OH

: 847165-24-6
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-2-methylpropanoyl-L-phenylalanine tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / tetrahydrofuran / 60 h / 20 °C

2: 74 percent / aq. HCl / acetonitrile / 20 °C

3: 69 percent / PyBOP; N-ethyl-diisopropylamine / CH₂Cl₂; acetonitrile / 20 °C

4: 91 percent / aq. HCl / H₂O; acetonitrile / 20 °C

5: 81 percent / PyBOP; N-ethyl-diisopropylamine / CH₂Cl₂; acetonitrile / 20 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1002/hlca.200490275