(+)-N-(benzyloxycarnonyl)-cis,cis-2(S)-<(methoxymethoxy)methyl>-4(R)-(methoxymethoxy)-6(R)-(hydroxymethyl)piperidine

Base Information

Chemical Name:(+)-N-(benzyloxycarnonyl)-cis,cis-2(S)-<(methoxymethoxy)methyl>-4(R)-(methoxymethoxy)-6(R)-(hydroxymethyl)piperidine
CAS No.:224647-27-2
Molecular Formula:C₁₉H₂₉NO₇
Molecular Weight:383.442
Hs Code.:

Synonyms:(+)-N-(benzyloxycarnonyl)-cis,cis-2(S)-<(methoxymethoxy)methyl>-4(R)-(methoxymethoxy)-6(R)-(hydroxymethyl)piperidine

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Chemical Property of (+)-N-(benzyloxycarnonyl)-cis,cis-2(S)-<(methoxymethoxy)methyl>-4(R)-(methoxymethoxy)-6(R)-(hydroxymethyl)piperidine

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Technology Process of (+)-N-(benzyloxycarnonyl)-cis,cis-2(S)-<(methoxymethoxy)methyl>-4(R)-(methoxymethoxy)-6(R)-(hydroxymethyl)piperidine

There total 2 articles about (+)-N-(benzyloxycarnonyl)-cis,cis-2(S)-<(methoxymethoxy)methyl>-4(R)-(methoxymethoxy)-6(R)-(hydroxymethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 177341-40-1
(-)-N-(benzyloxycarnonyl)-cis,cis-2(R)-(acetoxymethyl)-4(S)-(methoxymethoxy)-6(S)-<(methoxymethoxy)methyl>piperidine

: 224647-27-2
(+)-N-(benzyloxycarnonyl)-cis,cis-2(S)-<(methoxymethoxy)methyl>-4(R)-(methoxymethoxy)-6(R)-(hydroxymethyl)piperidine

Guidance literature:: With sodium hydroxide; phosphate buffer; In water; for 24h; Ambient temperature;
DOI:10.1021/jo9823036

Reference yield:

: 177341-65-0
(2R,4S,6S)-2-Acetoxymethyl-6-hydroxymethyl-4-methoxymethoxy-piperidine-1-carboxylic acid benzyl ester

: 224647-27-2
(+)-N-(benzyloxycarnonyl)-cis,cis-2(S)-<(methoxymethoxy)methyl>-4(R)-(methoxymethoxy)-6(R)-(hydroxymethyl)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / DIPEA / CH₂Cl₂ / 15 h / 0 - 20 °C

2: 85 percent / PLE, phosphate buffer, NaOH / H₂O / 24 h / Ambient temperature

With sodium hydroxide; phosphate buffer; N-ethyl-N,N-diisopropylamine; In dichloromethane; water;
DOI:10.1021/jo9823036

Reference yield: 78.0%

: 224647-27-2
(+)-N-(benzyloxycarnonyl)-cis,cis-2(S)-<(methoxymethoxy)methyl>-4(R)-(methoxymethoxy)-6(R)-(hydroxymethyl)piperidine

: 224647-28-3
(-)-N-(benzyloxycarnonyl)-cis,cis-4(S)-(methoxymethoxy)-6(S)-<(methoxymethoxy)methyl>piperidine-2(R)-carboxylic acid

Guidance literature:: With ruthenium trichloride; sodium periodate; In tetrachloromethane; water; acetonitrile; Ambient temperature;
DOI:10.1021/jo9823036