2-(4-(3-chloro-4-(2,4-dichlorophenylsulfonamido)-2-methyl-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

Base Information

Chemical Name:2-(4-(3-chloro-4-(2,4-dichlorophenylsulfonamido)-2-methyl-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid
CAS No.:1080520-84-8
Molecular Formula:C₂₄H₁₉Cl₃N₂O₆S
Molecular Weight:569.85
Hs Code.:

Synonyms:2-(4-(3-chloro-4-(2,4-dichlorophenylsulfonamido)-2-methyl-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

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Chemical Property of 2-(4-(3-chloro-4-(2,4-dichlorophenylsulfonamido)-2-methyl-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

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Technology Process of 2-(4-(3-chloro-4-(2,4-dichlorophenylsulfonamido)-2-methyl-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

There total 10 articles about 2-(4-(3-chloro-4-(2,4-dichlorophenylsulfonamido)-2-methyl-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1080520-82-6
2-(4-(4-(2,4-dichlorophenylsulfonamido)-2-methyl-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

: 1080520-84-8
2-(4-(3-chloro-4-(2,4-dichlorophenylsulfonamido)-2-methyl-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

Guidance literature:: With N-chloro-succinimide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmcl.2014.04.092

Reference yield:

: 1080521-36-3
2-(3-methoxy-4-(2-methyl-4-nitro-1H-indol-5-yloxy)phenyl)acetic acid

: 1080520-84-8
2-(4-(3-chloro-4-(2,4-dichlorophenylsulfonamido)-2-methyl-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid

2: tin(ll) chloride / ethyl acetate / Reflux

3: pyridine / 20 °C

4: lithium hydroxide; water / methanol / 20 °C

5: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

With pyridine; N-chloro-succinimide; sulfuric acid; water; tin(ll) chloride; lithium hydroxide; In methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.04.092

Reference yield:

: 1080521-35-2
2-(4-(4-amino-2-nitrophenoxy)-3-methoxyphenyl)acetic acid

: 1080520-84-8
2-(4-(3-chloro-4-(2,4-dichlorophenylsulfonamido)-2-methyl-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: potassium tert-butylate / dimethyl sulfoxide / 20 °C

2: sulfuric acid

3: tin(ll) chloride / ethyl acetate / Reflux

4: pyridine / 20 °C

5: lithium hydroxide; water / methanol / 20 °C

6: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

With pyridine; N-chloro-succinimide; sulfuric acid; potassium tert-butylate; water; tin(ll) chloride; lithium hydroxide; In methanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.04.092