N⁵-[6-Methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-hexane-1,5-diamine

Base Information

• Chemical Name: N⁵-[6-Methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-hexane-1,5-diamine
• CAS No.: 91860-26-3
• Molecular Formula: C₂₄H₂₈F₃N₃O₂
• Molecular Weight: 447.5

Synonyms:N⁵-[6-Methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-hexane-1,5-diamine

Chemical Property of N⁵-[6-Methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-hexane-1,5-diamine

Chemical Property:

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Technology Process of N⁵-[6-Methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-hexane-1,5-diamine

There total 3 articles about N⁵-[6-Methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-hexane-1,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

6-methoxy-4-methyl-8-<(5-phtalimido-1-methylpentyl)amino>5-(3-trifluoromethylphenoxy)quinoline (91860-25-2) → N5-[6-Methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-hexane-1,5-diamine (91860-26-3)

Guidance literature:

With hydrazine hydrate; In ethanol; for 4h; Heating;

DOI:10.1002/jhet.5570210108

Reference yield:

5-iodo-1-phtalimidohexane (91870-63-2) → N5-[6-Methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-hexane-1,5-diamine (91860-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / sodium bicarbonate / ethanol / 48 h / Heating

2: 77 percent / 95percent aq. hydrazine / ethanol / 4 h / Heating

With sodium hydrogencarbonate; hydrazine hydrate; In ethanol;

DOI:10.1002/jhet.5570210108

Reference yield:

8-amino-6-methoxy-4-methyl-5-(3-trifluoromethylphenoxy)quinoline (82333-41-3) → N5-[6-Methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-hexane-1,5-diamine (91860-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / sodium bicarbonate / ethanol / 48 h / Heating

2: 77 percent / 95percent aq. hydrazine / ethanol / 4 h / Heating

With sodium hydrogencarbonate; hydrazine hydrate; In ethanol;

DOI:10.1002/jhet.5570210108

upstream raw materials:

6-methoxy-4-methyl-8-<(5-phtalimido-1-methylpentyl)amino>5-(3-trifluoromethylphenoxy)quinoline

5-iodo-1-phtalimidohexane

8-amino-6-methoxy-4-methyl-5-(3-trifluoromethylphenoxy)quinoline

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