(2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((3-chlorobenzyl)carbamoyl)pyrrolidine-1-

Base Information

Chemical Name:(2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((3-chlorobenzyl)carbamoyl)pyrrolidine-1-
CAS No.:1360616-40-5
Molecular Formula:C₃₁H₃₃ClN₂O₄
Molecular Weight:533.067
Hs Code.:

Synonyms:(2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((3-chlorobenzyl)carbamoyl)pyrrolidine-1-

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Chemical Property of (2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((3-chlorobenzyl)carbamoyl)pyrrolidine-1-

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Technology Process of (2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((3-chlorobenzyl)carbamoyl)pyrrolidine-1-

There total 1 articles about (2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((3-chlorobenzyl)carbamoyl)pyrrolidine-1- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 268729-12-0
(2S,4R)-4-tert-butoxy-1-(9H-fluoren-9-ylmethoxycarbonyl)pyrrolidine-2-carboxylic acid

: 4152-90-3
m-chlorobenzylamine

: 1360616-40-5
(2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((3-chlorobenzyl)carbamoyl)pyrrolidine-1-

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 4 - 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/ja209924v

Reference yield: 46.0%

: 1360616-40-5
(2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((3-chlorobenzyl)carbamoyl)pyrrolidine-1-

: 1360616-42-7
(2S,4R)-4-(tert-butoxy)-N-(3-chlorobenzyl)pyrrolidine-2-carboxamide

Guidance literature:: With piperidine; In dichloromethane; at 4 - 20 ℃; for 15h; Inert atmosphere;
DOI:10.1021/ja209924v

Reference yield:

: 1360616-40-5
(2S,4R)-(9H-fluoren-9-yl)methyl 4-(tert-butoxy)-2-((3-chlorobenzyl)carbamoyl)pyrrolidine-1-

: 1360616-44-9
(2S,4R)-4-(tert-butoxy)-N-(3-chlorobenzyl)-1-(2-(3-methylisoxazol-5-yl)acetyl)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / dichloromethane / 15 h / 4 - 20 °C / Inert atmosphere

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 14 h / 4 - 20 °C / Inert atmosphere

With piperidine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja209924v