Fmoc-4-(phosphonomethyl)-phenylalanine

Base Information

Chemical Name:Fmoc-4-(phosphonomethyl)-phenylalanine
CAS No.:229180-65-8
Molecular Formula:C₂₅H₂₄NO₇P
Molecular Weight:481.442
Hs Code.:
DSSTox Substance ID:DTXSID301150493

Synonyms:229180-65-8;Fmoc-4-(phosphonomethyl)-phenylalanine;SCHEMBL12686942;DTXSID301150493;MFCD02092974;AKOS030212471;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(phosphonomethyl)-D-phenylalanine;N-alpha-(9-Fluorenylmethyloxycarbonyl)-4-phosphonomethyl-D-phenylalanine (Fmoc-D-Pmp-OH)

Suppliers and Price of Fmoc-4-(phosphonomethyl)-phenylalanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Fmoc-4-(phosphonomethyl)-phenylalanine

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:9
Exact Mass:481.12903910
Heavy Atom Count:34
Complexity:740

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CC4=CC=C(C=C4)CP(=O)(O)O)C(=O)O
Isomeric SMILES:C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)N[C@H](CC4=CC=C(C=C4)CP(=O)(O)O)C(=O)O

Technology Process of Fmoc-4-(phosphonomethyl)-phenylalanine

There total 4 articles about Fmoc-4-(phosphonomethyl)-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 142434-80-8
4-(phosphonomethyl)-D-phenylalanine

: 229180-65-8
N-Fmoc-D-Pmp

Guidance literature:: With sodium hydrogencarbonate; In water; acetone; Ambient temperature;
DOI:10.1080/00397919908086231

Reference yield:

: 2361-96-8,4134-09-2,57772-79-9,20918-84-7
(R)-ethyl N-acetylphenylalanine

: 229180-65-8
N-Fmoc-D-Pmp

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / ZnCl₂ / 8 h / 6 - 8 °C

2: 80 percent / 5 h / Heating

3: 90 percent / HCl / H₂O / 16 h / Heating

4: 97 percent / NaHCO₃ / acetone; H₂O / Ambient temperature

With hydrogenchloride; sodium hydrogencarbonate; zinc(II) chloride; In water; acetone;
DOI:10.1080/00397919908086231

Reference yield:

: 130887-69-3
N-Ac-D-Phe(p-CH₂Cl).OEt

: 229180-65-8
N-Fmoc-D-Pmp

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / 5 h / Heating

2: 90 percent / HCl / H₂O / 16 h / Heating

3: 97 percent / NaHCO₃ / acetone; H₂O / Ambient temperature

With hydrogenchloride; sodium hydrogencarbonate; In water; acetone;
DOI:10.1080/00397919908086231